Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area

Archives of Neurology
Sang Won SeoJi Hoe Heo

Abstract

The nucleus prepositus hypoglossi (NPH) is known to be a neural integrator of horizontal eye movements. Although the role of the human NPH is not well known, it may also function in postural balance, in view of its anatomic connections with the vestibular nuclei and vestibulocerebellum and of lesion studies in experimental animals. To show that the human NPH contributes to vestibular function in addition to eye movement control. Case series. University hospital. Patients Six patients with small and discrete brainstem infarctions that predominantly involved the NPH region.Main Outcome Measure Findings on magnetic resonance images. The NPH was affected at the lower pontine level in 2 patients and at the upper medullary level in 4. In addition to gaze-evoked nystagmus, all patients had vertigo, vomiting, and postural ataxia, suggesting vestibular dysfunction. The patients typically fell contralaterally or bilaterally to the lesion side. The NPH serves a vestibular function in addition to its oculomotor control function.

Citations

Sep 2, 2006·Stroke; a Journal of Cerebral Circulation·Kevin A KerberLewis B Morgenstern
Feb 1, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jae Hyun ParkDuk L Na
Nov 27, 2015·Brain Research·David Weinshenker, Philip V Holmes
Aug 30, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Diego ClementeFernando De Castro
Mar 5, 2015·Annals of the New York Academy of Sciences·Sung-Hee KimJi-Soo Kim
Nov 23, 2016·Acta Ophthalmologica·Katherine Sanchez, Fiona J Rowe
Nov 13, 2017·Acta neurologica Belgica·Sung-Hee Kim, Ji-Soo Kim
Oct 16, 2015·Stroke; a Journal of Cerebral Circulation·Sun-Uk LeeJi-Soo Kim
Apr 10, 2019·Acta neurologica Belgica·Chenguang ZhouYaoyao Shen
Feb 6, 2020·Brain, Behavior, and Immunity·Monokesh K SenPeter J Shortland

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