Vestibular modulation of muscle sympathetic nerve activity assessed over a 100-fold frequency range of sinusoidal galvanic vestibular stimulation

Journal of Neurophysiology
Natasha SinghVaughan G Macefield

Abstract

We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered at 0.2-2.0 Hz, evokes a partial entrainment of muscle sympathetic nerve activity (MSNA). Moreover, at lower frequencies of stimulation (0.08-0.18 Hz) sGVS produces two peaks of modulation: one (primary) peak associated with the positive peak of the sinusoidal stimulus and a smaller (secondary) peak associated with the trough. Here we assessed whether sGVS delivered at 0.05 Hz causes a more marked modulation of MSNA than at higher frequencies and tested the hypothesis that the primary and secondary peaks are of identical amplitude because of the longer cycle length. MSNA was recorded via tungsten microelectrodes inserted into the left peroneal nerve in 11 seated subjects. Bipolar binaural sGVS (±2 mA, 100 cycles) was applied to the mastoid processes at 0.05, 0.5, and 5.0 Hz (500 cycles). Cross-correlation analysis revealed two bursts of modulation of MSNA for each cycle at 0.05 and 0.5 Hz but only one at 5 Hz. There was a significant inverse linear relationship between vestibular modulation (primary peak) and frequency (P < 0.0001), with the amplitudes of the peaks being highest at 0.05 Hz. Moreover, the secondary peak at this frequency wa...Continue Reading

References

Mar 27, 2002·Experimental Brain Research·H KaufmannB Cohen
Nov 26, 2005·Experimental Brain Research·Andrei VoustianioukBernard Cohen
May 25, 2006·Experimental Brain Research·Leah R BentVaughan G Macefield
Jan 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason R Carter, Chester A Ray
Apr 21, 2009·Autonomic Neuroscience : Basic & Clinical·Kunihiko TanakaHironobu Morita
Aug 3, 2010·Autonomic Neuroscience : Basic & Clinical·Cheree James, Vaughan G Macefield
Mar 5, 2011·Experimental Brain Research·Bernard CohenSergei B Yakushin
Nov 18, 2011·Autonomic Neuroscience : Basic & Clinical·Kunihiko TanakaHironobu Morita
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Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard CohenSergei B Yakushin
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Apr 29, 2014·Frontiers in Neurology·Sergei B YakushinBernard Cohen
Sep 23, 2016·Journal of Neurophysiology·Vaughan G Macefield, Cheree James
Apr 1, 2017·Frontiers in Neurology·Bernard CohenSergei B Yakushin
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Aug 12, 2017·Frontiers in Neurology·Elie Hammam, Vaughan G Macefield

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