Abstract
Starting a week after they were hatched, chicks received daily subcutaneous injections of streptomycin sulfate for 15 or 30 days at one of three dosages: 400, 800, or 1,200 mg/kg body weight. During the period of administration, the chicks were weighed, examined for signs of systemic intoxication, and tested for impairment of equilibrium. At intervals some birds from each group were sacrificed and the end-organs of the semicircular canals were examined for damage. After the fifteenth injection, the weights of the control and experimental chicks were similar. By comparison, the chicks that received streptomycin injections showed varying degrees of impairment of equilibrium. First, some birds in the three experimental groups began to tremble at least slightly by the third injections, but others, particularly at the highest dosage (1,200 mg/kg body weight), trembled severely by the fifth injections. However, trembling began to subside in the lowest-dosage (400 mg/kg body weight) group by the fourteenth injection. Second, the chicks' ability to perch on dowels, either hooded or unhooded, and their ability to perch on the investigator's fingers in the dark deteriorated. Perching performances on the dowel deteriorated conspicuously o...Continue Reading
References
Mar 1, 1976·Archives of Otolaryngology·D S PostmaN D Fischer
Sep 1, 1973·Audiology : Official Organ of the International Society of Audiology·M Igarashi
Sep 1, 1973·Audiology : Official Organ of the International Society of Audiology·H StuppM Quante
Sep 1, 1973·Audiology : Official Organ of the International Society of Audiology·E Hawkins
Feb 1, 1969·Acta Oto-laryngologica·H H Lindeman
Jan 1, 1966·Acta Oto-laryngologica·M IgarashiA Graybiel
Jun 1, 1966·The Anatomical Record·M Igarashi, T Yoshinobu
Jan 1, 1968·Acta Oto-laryngologica·M Igarashi
Dec 1, 1968·Acta Oto-laryngologica·M Nagaba
Apr 1, 1970·Acta Oto-laryngologica·M IgarashiP M Maxian
Jun 1, 1969·The Annals of Otology, Rhinology, and Laryngology·R S Kimura
Aug 1, 1967·Archives of Otolaryngology·C Fernández
Feb 1, 1981·Archives of Otolaryngology·A J DuvallP A Santi
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Mar 1, 1961·Transactions - American Academy of Ophthalmology and Otolaryngology·T M MCGEE
Apr 1, 1963·The Journal of Cell Biology·E S REYNOLDS
Jan 1, 1962·Acta Oto-laryngologica·J WERSALL, J E HAWKINS
Jun 1, 1964·Acta Oto-laryngologica·A J DUVALL, J WERSAELL
Apr 16, 1965·Science·T L POULSON
Citations
Jan 1, 1987·Hearing Research·C D FerminT Yoshihara
Jul 31, 1998·Hearing Research·S M JonesS Colbert
Dec 14, 2001·Neuroreport·M SuzukiK Kaga
Jun 20, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Silvia QuaglieriMarco Benazzo
Mar 21, 2015·PloS One·Jianping LiuPeter S Steyger
Oct 12, 2004·Otolaryngologic Clinics of North America·John Carey
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Frank R LinJohn P Carey
Nov 1, 1988·The Annals of Otology, Rhinology, and Laryngology·R S KimuraR E Southard
May 6, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H SilversteinT O Hester
Jan 15, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nathalie Gabra, Issam Saliba
Jan 1, 1994·Toxicologic Pathology·J D FikesS D Sleight
Aug 15, 2000·The Laryngoscope·D M KaplanD B Shipp
Jun 9, 1998·Annals of the New York Academy of Sciences·D Bagger-Sjoback
Dec 1, 1990·Clinical Otolaryngology and Allied Sciences·K Laitakari
Dec 18, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Daniel BodmerJulian M Nedzelski
Mar 15, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yuyao ZhangJueting Wu
Dec 4, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Furkan YazHans G X M Thomeer
Jul 26, 2000·Acta Oto-laryngologica. Supplementum·S CharabiM Tos
Apr 6, 2004·The Laryngoscope·Takeshi OkudaHiroshi Yamashita
Oct 3, 2007·The Laryngoscope·Kai HellingAndrew H Clarke
Feb 9, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Francesco FiorinoAlberto Beltramello
Jul 1, 1984·Acta Oto-laryngologica·J C Park, G M Cohen
Nov 10, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B J BaloughM Goto
May 1, 1989·American Journal of Otolaryngology·L R Proctor, Y el-Kashef
Sep 1, 1985·American Journal of Otolaryngology·D J Pender