Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise

PloS One
Jacob B LindheimerMichael J Falvo

Abstract

The components of minute ventilation, respiratory frequency and tidal volume, appear differentially regulated and thereby afford unique insight into the ventilatory response to exercise. However, respiratory frequency and tidal volume are infrequently reported, and have not previously been considered among military veterans with Gulf War Illness. Our purpose was to evaluate respiratory frequency and tidal volume in response to a maximal cardiopulmonary exercise test in individuals with and without Gulf War Illness. 20 cases with Gulf War Illness and 14 controls participated in this study and performed maximal cardiopulmonary exercise test on a cycle ergometer. Ventilatory variables (minute ventilation, respiratory frequency and tidal volume) were obtained and normalized to peak exercise capacity. Using mixed-design analysis of variance models, with group and time as factors, we analyzed exercise ventilatory patterns for the entire sample and for 11 subjects from each group matched for race, age, sex, and height. Despite similar minute ventilation (p = 0.57, η2p = 0.01), tidal volume was greater (p = 0.02, η2p = 0.16) and respiratory frequency was lower (p = 0.004, η2p = 0.24) in Veterans with Gulf War Illness than controls. The...Continue Reading

References

May 1, 1992·Journal of Applied Physiology·E A AaronJ A Dempsey
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Jun 1, 1986·Journal of Applied Physiology·W L BeaverB J Whipp
Oct 1, 1993·The Journal of Physiology·P A Martin, G S Mitchell
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Aug 31, 2001·Medicine and Science in Sports and Exercise·O InbarB J Whipp
Aug 6, 2002·Respiratory Physiology & Neurobiology·Duncan Turner, D Paul Sumners
Mar 15, 2003·JAMA : the Journal of the American Medical Association·Sam T DontaVA Cooperative Study #470 Study Group
Mar 29, 2003·The European Respiratory Journal·J A NederL E Nery
Apr 4, 2003·Medicine and Science in Sports and Exercise·Dane B CookBenjamin H Natelson
Sep 30, 2003·The Journal of Physiology·Helen E WoodPeter A Robbins
Nov 24, 2004·The Journal of Pain : Official Journal of the American Pain Society·Dennis C TurkTasha Burwinkle
Dec 15, 2004·Archives of Internal Medicine·Joel B KarlinskyDomenic J Reda
Sep 13, 2005·Respiratory Physiology & Neurobiology·Harold J Bell, James Duffin
Dec 17, 2008·Psychosomatic Medicine·Joshua A Grant, Pierre Rainville
Mar 7, 2009·BMC Medical Genomics·Toni WhistlerNancy Klimas
Aug 13, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Philippe ChalayeSerge Marchand
Mar 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Dane B CookLaura D Ellingson
Oct 20, 2010·Brain, Behavior, and Immunity·Gordon BroderickNancy Klimas
Aug 10, 2011·Journal of Experimental Psychology. General·Catherine O FritzJennifer J Richler
Sep 24, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Volker BuschPeter Eichhammer
Dec 4, 2012·Brain, Behavior, and Immunity·Gordon BroderickNancy Klimas
Nov 12, 2013·Respiratory Physiology & Neurobiology·David A TannerJoel M Stager
Oct 24, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Roberta F WhiteRachel Grashow
Oct 28, 2015·Journal of Sports Sciences·Andrea NicolòMassimo Sacchetti
Jun 1, 2017·Experimental Physiology·Andrea NicolòMassimo Sacchetti
Jan 13, 2018·Frontiers in Physiology·Andrea NicolòLouis Passfield

Citations

Sep 6, 2020·Physiological Reports·Jacob B LindheimerMichael J Falvo
Jun 20, 2020·Medicine and Science in Sports and Exercise·Ellen E BarhorstJacob B Lindheimer

Related Concepts

Cardiopulmonary Exercise Test
Pulse Rate
Respiration
Tidal Volume
Environmental Air Flow
Veterans
Gulf War
Self-Report
Cor Pulmonale
Racial Group

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