VE/VCO2 slope and its prognostic value in patients with chronic heart failure

Experimental and Therapeutic Medicine
Yuqin ShenLemin Wang

Abstract

The minute ventilation/carbon dioxide production (VE/VCO2) slope has been widely demonstrated to have strong prognostic value in patients with chronic heart failure (CHF), and the risk of mortality is believed to increase when the VE/VCO2 slope is >32.8; however, there is little evidence concerning the prognostic value of the VE/VCO2 slope in Chinese patients. In the present study, the prognostic value of the VE/VCO2 slope was investigated in patients with CHF. A total of 258 subjects underwent symptom-limited cardiopulmonary exercise testing (CPET) and were divided into CHF (113 males and 16 females; LVEF <0.49) and control (106 males and 23 females) groups. The cardiac-related events over a median 33.7-month follow-up period subsequent to the CPET were evaluated using receiver operating characteristic curve analysis. The VE/VCO2 slope was significantly different between the CHF and control groups (P<0.001). The area under the curve (AUC) for the VE/VCO2 slope in predicting cardiac-related mortalities in the patients with CHF was 0.670 (P<0.05), and the sensitivity and specificity of the VE/VCO2 slope were 0.667 and 0.620, respectively. The optimal threshold of the VE/VCO2 slope for predicting cardiac-related mortalities in pa...Continue Reading

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Citations

Jun 23, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D M L PradoV Furlan
Feb 25, 2021·Cardiology in the Young·Richard J DobsonMark H D Danton
Mar 21, 2020·Journal of the American College of Cardiology·Sean P MurphyJames L Januzzi
Jul 14, 2021·Respiratory Physiology & Neurobiology·Joshua Broadman, Dennis Jensen
Oct 7, 2021·Disability and Rehabilitation·Matheus Ribeiro ÁvilaHenrique Silveira Costa

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