Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis.

International Journal of Medical Sciences
Zhong ZhaoG M Pasinetti

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Previous proteomic evidence revealed that the content of certain peptide fragments including Vgf-derived peptide aa 398-411 (Vgf(398-411)) of the precursor Vgf protein in the cerebral spinal fluid (CSF) correctly identified patients with ALS from normal and disease controls. Using quantitative ELISA immunoassay we found that the CSF levels of Vgf decreases with muscle weakness in patients with ALS. In SOD1 G93A transgenic mice, loss of full-length Vgf content in CSF, serum and in SMI-32 immunopositive spinal cord motor neurons is noted in asymptomatic animals (approximately 75 days old) and continues to show a progressive decline as animals weaken. In vitro studies show that viral-mediated exogenous Vgf expression in primary mixed spinal cord neuron cultures attenuates excitotoxic injury. Thus, while Vgf may be a reliable biomarker of progression of muscle weakness in patients with ALS, restoration of Vgf expression in spinal cord motor neurons may therapeutically rescue spinal cord motorneurons against excitotoxic injury.

References

Sep 15, 1994·The Journal of Comparative Neurology·A N van den PolP Ghosh
Jul 1, 1997·Nature Medicine·C Nyberg-HoffmanE Aguilar-Cordova
Apr 29, 1998·The Journal of Comparative Neurology·S E Snyder, S R Salton
Feb 19, 2002·Neurochemistry International·Fiona M MenziesPamela J Shaw
Jun 7, 2002·The Journal of Biological Chemistry·Marina MattiazziGiovanni Manfredi
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P N PomplG M Pasinetti
Jul 6, 2004·Cellular and Molecular Neurobiology·Andrea LeviStephen R J Salton
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luc DupuisJean-Philippe Loeffler
Feb 17, 2006·Neurology·G M PasinettiL Ho
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·A BartolomucciA Moles
Apr 28, 2007·Endocrinology·Preeti H JethwaFrancis J P Ebling
Jul 5, 2007·The Journal of Biological Chemistry·Hideki YamaguchiNaoto Minamino
Dec 7, 2007·Nature Medicine·Joshua G HunsbergerRonald S Duman

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Citations

Feb 19, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annamaria CattaneoMassimo Gennarelli
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Apr 22, 2010·Biomarkers in Medicine·Jeban Ganesalingam, Robert Bowser
Jun 15, 2013·Beilstein Journal of Organic Chemistry·Allison S LimpertNicholas D P Cosford
Feb 26, 2013·Journal of Neurology·Hirotaka TanakaHideaki Hara
Aug 12, 2009·Muscle & Nerve·Robert Bowser, David Lacomis
Oct 23, 2012·Psychoneuroendocrinology·Laura W HarrisSabine Bahn
Feb 24, 2015·Frontiers in Endocrinology·Jo E LewisPreeti H Jethwa
Nov 13, 2015·PloS One·Filomena D'AmatoCristina Cocco
Sep 2, 2011·Epilepsy Research·S A MasinoD Boison
Aug 30, 2011·Epilepsy Research·Adam L Hartman
Mar 14, 2017·International Journal of Molecular Sciences·Joseph BehnkeJanet Alder
Dec 24, 2018·Proteomics. Clinical Applications·Gajanan SatheAkhilesh Pandey
Jan 1, 2013·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Matteo BoniniSergio Bonini
Aug 12, 2017·Expert Review of Proteomics·Peggy BarschkeMarkus Otto
Jun 20, 2017·Frontiers in Cellular Neuroscience·Barbara NoliCristina Cocco
Dec 24, 2018·Journal of Neuroscience Research·Suzhen ChenYonggui Yuan
Jan 9, 2019·Frontiers in Cellular Neuroscience·Kathleen JordanCassie S Mitchell
Feb 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ryann M FameHazel L Sive
Sep 25, 2019·International Journal of Molecular Sciences·Inger van SteenovenCharlotte E Teunissen
Aug 4, 2020·Neuroscience Insights·Tessa Bergsma, Ekaterina Rogaeva
Oct 7, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·J B DelayeH Blasco
Nov 17, 2020·Frontiers in Neuroscience·Giovanna MorelloSebastiano Cavallaro

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Methods Mentioned

BETA
ELISA
fluoresce microscopy
transgenic

Software Mentioned

SigmaStat
SPSS
Bioquant
Neurolucida

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