VGluT3-expressing CCK-positive basket cells construct invaginating synapses enriched with endocannabinoid signaling proteins in particular cortical and cortex-like amygdaloid regions of mouse brains

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yuki OmiyaMasahiko Watanabe

Abstract

Invaginating synapses in the basal amygdala are a unique type of GABAergic synapses equipped with molecular-anatomical organization specialized for 2-arachidonoylglycerol (2-AG)-mediated endocannabinoid signaling. Cholecystokinin (CCK)-positive basket cell terminals protrude into pyramidal cell somata and form invaginating synapses, where apposing presynaptic and postsynaptic elements are highly loaded with cannabinoid receptor CB₁ or 2-AG synthetic enzyme diacylglycerol lipase-α (DGLα), respectively. The present study scrutinized their neurochemical and neuroanatomical phenotypes in adult mouse telencephalon. In the basal amygdala, vesicular glutamate transporter-3 (VGluT3) was transcribed in one-fourth of CB₁-expressing GABAergic interneurons. The majority of VGluT3-positive CB₁-expressing basket cell terminals apposed DGLα clusters, whereas the majority of VGluT3-negative ones did not. Importantly, VGluT3-positive basket cell terminals selectively constructed invaginating synapses. GABAA receptors accumulated on the postsynaptic membrane of invaginating synapses, whereas metabotropic glutamate receptor-5 (mGluR₅) was widely distributed on the somatodendritic surface of pyramidal cells. Moreover, CCK₂ receptor (CCK₂R) was hig...Continue Reading

Citations

Apr 10, 2017·Brain Structure & Function·Laura Rovira-EstebanNorbert Hájos
Jun 24, 2017·Brain Structure & Function·Patrizia PanzanelliJean-Marc Fritschy
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Sep 2, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arnau Busquets-GarciaGiovanni Marsicano
Apr 14, 2019·The Journal of Comparative Neurology·Alexander J McDonald, Franco Mascagni
Apr 23, 2019·The Journal of Comparative Neurology·Megan L FitzgeraldVirginia M Pickel
Jan 9, 2019·Frontiers in Neural Circuits·Louis-Eric Trudeau, Salah El Mestikawy
Apr 21, 2018·Frontiers in Synaptic Neuroscience·Ronald S PetraliaPamela J Yao
Jun 1, 2017·Frontiers in Cellular Neuroscience·Caroline FasanoSalah El Mestikawy
Mar 30, 2021·Trends in Pharmacological Sciences·Mathieu FavierGiuseppe Gangarossa
Jun 11, 2021·Frontiers in Synaptic Neuroscience·Ronald S PetraliaYa-Xian Wang
Jun 29, 2021·Frontiers in Neural Circuits·Norbert Hájos

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