Abstract
Invaginating synapses in the basal amygdala are a unique type of GABAergic synapses equipped with molecular-anatomical organization specialized for 2-arachidonoylglycerol (2-AG)-mediated endocannabinoid signaling. Cholecystokinin (CCK)-positive basket cell terminals protrude into pyramidal cell somata and form invaginating synapses, where apposing presynaptic and postsynaptic elements are highly loaded with cannabinoid receptor CB₁ or 2-AG synthetic enzyme diacylglycerol lipase-α (DGLα), respectively. The present study scrutinized their neurochemical and neuroanatomical phenotypes in adult mouse telencephalon. In the basal amygdala, vesicular glutamate transporter-3 (VGluT3) was transcribed in one-fourth of CB₁-expressing GABAergic interneurons. The majority of VGluT3-positive CB₁-expressing basket cell terminals apposed DGLα clusters, whereas the majority of VGluT3-negative ones did not. Importantly, VGluT3-positive basket cell terminals selectively constructed invaginating synapses. GABAA receptors accumulated on the postsynaptic membrane of invaginating synapses, whereas metabotropic glutamate receptor-5 (mGluR₅) was widely distributed on the somatodendritic surface of pyramidal cells. Moreover, CCK₂ receptor (CCK₂R) was hig...Continue Reading
Citations
May 27, 2015·Neuromolecular Medicine·Ronald S PetraliaPamela J Yao
Mar 16, 2016·Molecular Psychiatry·G A VargishC J McBain
Apr 10, 2017·Brain Structure & Function·Laura Rovira-EstebanNorbert Hájos
Jun 24, 2017·Brain Structure & Function·Patrizia PanzanelliJean-Marc Fritschy
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Sep 2, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arnau Busquets-GarciaGiovanni Marsicano
Apr 14, 2019·The Journal of Comparative Neurology·Alexander J McDonald, Franco Mascagni
Apr 23, 2019·The Journal of Comparative Neurology·Megan L FitzgeraldVirginia M Pickel
Feb 14, 2020·ELife·Kenneth A PelkeyChris J McBain
Apr 7, 2020·Cerebral Cortex·Chelsea S SullivanPatricia F Maness
Jun 15, 2017·Neuromolecular Medicine·Ronald S PetraliaPamela J Yao
Jan 9, 2019·Frontiers in Neural Circuits·Louis-Eric Trudeau, Salah El Mestikawy
Mar 11, 2018·The Journal of Comparative Neurology·Hajime ShiotaniYoshimi Takai
Apr 21, 2018·Frontiers in Synaptic Neuroscience·Ronald S PetraliaPamela J Yao
Sep 3, 2020·Molecular Pharmacology·Karim S IbrahimStephen S G Ferguson
Aug 30, 2020·Molecular Neurobiology·Diana E López, Santiago J Ballaz
Jun 1, 2017·Frontiers in Cellular Neuroscience·Caroline FasanoSalah El Mestikawy
Oct 10, 2020·ELife·Xingchen LiuAdam G Carter
Dec 29, 2020·Neuroscience·Alexander J McDonald
Dec 23, 2020·Neuroscience Letters·Alexander J McDonald
Dec 24, 2020·ELife·Motokazu UchigashimaKensuke Futai
Mar 30, 2021·Trends in Pharmacological Sciences·Mathieu FavierGiuseppe Gangarossa
Jun 11, 2021·Frontiers in Synaptic Neuroscience·Ronald S PetraliaYa-Xian Wang
Jun 29, 2021·Frontiers in Neural Circuits·Norbert Hájos