VH gene family repertoires of "viable motheaten" (mev) mice

European Journal of Immunology
A A Freitas, C L Sidman

Abstract

Mutant viable motheaten (mev) mice provide an useful experimental model to study the origin and molecular properties of autoantibodies. In the present investigation we have compared by in situ hybridization VH gene family usage in lipopolysaccharide-activated B cells (available repertoire) and spontaneously immunoglobulin-secreting (actual repertoire) B cells in the spleen of 6-8-week-old BALB/c and mutant BALB/c-mev mice. We have found that while sharing identical available splenic repertoires and expressing a diversified set of VH families, mev mice differ from control BALB/c animals in VH family representation in the actual plasma cell repertoires where they showed a decreased utilization of VH7183 genes and an increased representation of the VHJ606 family when compared to control BALB/c animals. These results indicate that selection of actual repertoires may indeed differ between autoimmune and control mice, but do not establish whether such changes are the primary cause of the disease or whether they are secondary to the initiating of the autoimmune process.

References

Sep 1, 1975·The Journal of Heredity·M C Green, L D Shultz
Jun 1, 1989·European Journal of Immunology·L AndradeA Coutinho
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanR D Allen
Sep 1, 1987·European Journal of Immunology·T Blankenstein, U Krawinkel
Oct 1, 1988·European Journal of Immunology·L ReiningerJ C Jaton
Aug 1, 1988·The Journal of Experimental Medicine·H D Jeong, J M Teale
Mar 1, 1988·The Journal of Experimental Medicine·C J PainterC A Bona
Jun 1, 1987·The Journal of Experimental Medicine·D M Klinman, A D Steinberg
Aug 2, 1987·Nature·M J ShlomchikM G Weigert
Feb 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R J Morris, P C Barber
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 1, 1984·The Journal of Experimental Medicine·R M PerlmutterL Hood
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaL A Herzenberg
Jan 1, 1987·Immunology Today·R KoflerA N Theofilopoulos
Apr 1, 1984·Immunology Today·R Dildrop

❮ Previous
Next ❯

Citations

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A A FreitasA Coutinho
Sep 1, 1991·European Journal of Immunology·L AndradeA Coutinho
Jan 1, 1992·International Reviews of Immunology·H H Wortis
Jan 1, 1993·Autoimmunity·K LeijonD Holmberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.