VHR/DUSP3 phosphatase: structure, function and regulation

The FEBS Journal
Karolina PavicMaja Köhn

Abstract

Vaccinia H1-related (VHR) phosphatase, also known as dual-specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases. VHR has a preference for phospho-tyrosine substrates, and has important roles in cellular signaling ranging from cell-cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR/DUSP3 has been implicated in several human cancers, where its tumor-suppressing and -promoting properties have been described. We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.

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Citations

Oct 5, 2016·ACS Chemical Biology·Sara FahsMaja Köhn
Jun 5, 2019·International Journal of Molecular Sciences·Roland Lang, Faizal A M Raffi
Aug 30, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maud M VandereykenSouad Rahmouni
Mar 15, 2019·International Journal of Molecular Sciences·Caroline E Nunes-XavierRafael Pulido
Jan 21, 2021·International Journal of Molecular Sciences·Elliott M Thompson, Andrew W Stoker
Apr 14, 2021·Cellular Signalling·Teerna Bhattacharyya, Ramanathan Sowdhamini
Apr 30, 2020·Biochemistry·Victor A BeaumontJ Patrick Loria
Jul 5, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wei QiuGang Li

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