VHS domain -- a longshoreman of vesicle lines

FEBS Letters
O LohiVeli Pekka Lehto

Abstract

The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·W T WongP P Di Fiore
Aug 23, 1996·Biochemical and Biophysical Research Communications·T TakeshitaK Sugamura
Sep 27, 1996·The Journal of Biological Chemistry·H StenmarkA D'Arrigo
Feb 27, 1997·Nature·A J BeanR H Scheller
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchultzC P Ponting
Aug 11, 1998·Nature·J M GaullierR Aasland
Feb 27, 1999·Protein Science : a Publication of the Protein Society·B K KayS D Emr
Jun 11, 1999·Current Opinion in Structural Biology·M R Groves, D Barford
Jan 29, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·H TakataN Kitamura
Mar 4, 2000·The Journal of Biological Chemistry·A PoussuV P Lehto
May 18, 2000·Biochemical and Biophysical Research Communications·H TakatsuK Nakayama
Sep 7, 2000·The Journal of Cell Biology·B QualmannR B Kelly
Nov 4, 2000·Biochemical and Biophysical Research Communications·S Murai, N Kitamura
Nov 4, 2000·The Journal of Cell Biology·M W Black, H R Pelham
Mar 13, 2001·Biochemical and Biophysical Research Communications·M Komada, N Kitamura
Apr 13, 2001·Cell·R PuertollanoJ S Bonifacino
Jun 2, 2001·Science·R PuertollanoJ S Bonifacino
Jun 16, 2001·Molecular Biology of the Cell·G CostagutaG S Payne
Aug 11, 2001·Biochemical Society Transactions·C RaiborgH Stenmark

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Citations

May 15, 2003·Biochemical and Biophysical Research Communications·Craig BlackstoneMorgan Sheng
Dec 31, 2002·Current Opinion in Structural Biology·Philip R Evans, David J Owen
Aug 18, 2004·Nature Biotechnology·Blagoy BlagoevMatthias Mann
Oct 25, 2006·Molecular and Cellular Biology·Nicole LaRonde-LeBlancNancy H Colburn
Feb 16, 2006·Molecular and Cellular Biology·Mélanie FrancoSerge Roche
Jun 15, 2007·BMC Genomics·Inbar Cohen-GihonRoded Sharan
Jan 28, 2004·Cell Structure and Function·Kazuhisa Nakayama, Soichi Wakatsuki
Jan 2, 2016·Cellular and Molecular Life Sciences : CMLS·Andrea M A SchreijPeter S McPherson
Oct 3, 2009·The EMBO Journal·Ning Sheng LiuWanjin Hong
Jan 27, 2011·The Plant Journal : for Cell and Molecular Biology·Etsuko ItabashiKinya Toriyama
Jun 7, 2011·The EMBO Journal·Yoshinori HiranoToshio Hakoshima
Dec 18, 2002·Proteins·Mario AlbrechtThomas Lengauer
Jan 22, 2005·Immunological Reviews·Marko PesuJohn J O'Shea
Jul 11, 2008·Immunological Reviews·Marko PesuJohn J O'Shea
Dec 5, 2008·Traffic·Cédric BlancFrançois Letourneur
Dec 8, 2005·Immunology Letters·Szabina FodorAttila Mócsai
Mar 26, 2002·FEBS Letters·Pietro De CamilliAxel T Brunger
Feb 27, 2020·Circulation Research·Shiju YeGuang Liang
Oct 18, 2003·The Journal of Biological Chemistry·Megumi YamakamiHideyoshi Yokosawa
Mar 30, 2004·The Journal of Biological Chemistry·Yohei KatohKazuhisa Nakayama
Jan 8, 2010·Gene Regulation and Systems Biology·Leonid V OmelyanchukLong-Sheng Chang
Nov 6, 2007·The Journal of Biological Chemistry·Juan ZhangReuben P Siraganian
Apr 23, 2008·Current Protocols in Protein Science·Peter D SunJeffrey C Boyington
May 16, 2019·Oxidative Medicine and Cellular Longevity·Matylda B MielcarskaFelix N Toka
Dec 6, 2003·Journal of Cell Science·Valerie Legendre-GuilleminPeter S McPherson

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