PMID: 6110821Mar 14, 1981Paper

Vi serology in the detection of typhoid carriers

Lancet
C M NolanK H Wong

Abstract

A new haemagglutination assay for Vi antibodies was evaluated in searches for symptom-free carriers of Salmonella typhi associated with sporadic cases of typhoid fever. The assay differs from previous ones in that a purified (instead of crude) Vi antigen from Citrobacter was used to sensitise the red blood cells. In ten sporadic outbreaks of typhoid stool culture identified seven enteric carriers of S. typhi among the patients' families or other close contacts. All seven carriers had Vi antibodies in titres ranging from 1:40 to 1:2560. Moreover, among thirty-seven stool-culture-negative contacts of patients, only one had Vi antibodies, in a titre of 1:10. Thus, the new assay for Vi antibodies was as sensitive and as specific as faecal culture in detecting symptom-free typhoid carriers. It could become a convenient screening test.

References

Dec 1, 1978·Canadian Journal of Microbiology·L K Ng, M E Stiles
Jan 1, 1979·The Journal of Infectious Diseases·R W Ryder, P A Blake
Aug 1, 1976·The Journal of Hygiene·P Y Chau, A C Chan
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Sep 1, 1964·American Journal of Public Health and the Nation's Health·V BOKKENHEUSERN RICHARDSON
Mar 25, 1944·British Medical Journal·S S Bhatnagar

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Citations

Feb 1, 1993·Epidemiology and Infection·F S YewY S Lim
Jan 18, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A GuptaE D Mintz
Jul 30, 2014·Trends in Microbiology·John S GunnEdward T Ryan
Jul 21, 2017·PLoS Neglected Tropical Diseases·Conall H WatsonW John Edmunds
Mar 10, 2000·The American Journal of Gastroenterology·U DuttaR K Tandon
Apr 1, 1983·Journal of Clinical Microbiology·T J BarrettJ C Feeley

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