Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient

Stroke; a Journal of Cerebral Circulation
Lisbeth RøhlCarsten Gyldensted

Abstract

The penumbra of ischemic stroke consists of hypoperfused, but not irreversibly damaged, tissue surrounding the ischemic core. The purpose of this study was to determine viability thresholds in the ischemic penumbra, defined as the perfusion/diffusion mismatch in hyperacute stroke, by the use of diffusion- and perfusion-weighted MRI (DWI and PWI, respectively). DWI and PWI were performed in 11 patients </=6 hours after the onset of symptoms of acute ischemic stroke. Regions of interest (ROIs) were placed covering the ischemic core (ROI 1), the penumbra that progressed to infarction on the basis of follow-up scans (ROI 2), and the penumbra that recovered (ROI 3). The ratios of relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), mean transit time (MTT), and apparent diffusion coefficient were calculated as lesion ROIs relative to the contralateral mirror ROIS: The post hoc analysis showed that the penumbra progressed to infarction at the following cutoff values: rCBF <0.59 and MTT >1.63. Higher sensitivity and accuracy in predicting outcome of the penumbra were obtained from the rCBF maps compared with the rCBV and MTT maps. The initial rCBV and apparent diffusion coefficient ratios did not differentiate be...Continue Reading

References

Oct 1, 1978·Seminars in Nuclear Medicine·C E Metz
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenM S Cohen
Jun 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenK K Kwong
Mar 1, 1991·Annals of Neurology·W J Powers
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A Lassen
Nov 1, 1984·Annals of Neurology·W J PowersM E Raichle
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Hoehn-BerlageK A Hossmann
Oct 1, 1994·Annals of Neurology·K A Hossmann
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D DavisP C van Zijl
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S PappataL Di Giamberardino
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Hoehn-BerlageK Yamashita
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E BuschK A Hossmann
Dec 3, 1999·Brain : a Journal of Neurology·G MarchalJ C Baron
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LiuH J Aronen

❮ Previous
Next ❯

Citations

Dec 25, 2002·Journal of Magnetic Resonance Imaging : JMRI·Helmut RumpelKim Ping Tan
Jul 29, 2009·Klinische Neuroradiologie·Thomas Kucinski
Dec 13, 2007·La Radiologia medica·A CianfoniL Bonomo
Sep 14, 2002·Seminars in Roentgenology·Pamela W SchaeferR Gilberto González
Feb 25, 2003·European Journal of Radiology·Matthias König
Nov 17, 2001·Magnetic Resonance Imaging·S E RoseJ Semple
May 28, 2011·Brain : a Journal of Neurology·Josef A AlawnehJean-Claude Baron
Apr 2, 2004·Topics in Magnetic Resonance Imaging : TMRI·Howard A Rowley, Timothy P L Roberts
Nov 13, 2004·Journal of Computer Assisted Tomography·Sotirios BisdasHartmut Becker
Jul 31, 2008·Journal of Computer Assisted Tomography·Hiroshi HagiwaraYasuo Katayama
Jun 5, 2013·Stroke; a Journal of Cerebral Circulation·Weili LinJin-Moo Lee
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Erica C Sá de Camargo, Walter J Koroshetz
Oct 16, 2008·The Keio Journal of Medicine·W-D Heiss, J Sobesky
Aug 12, 2005·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kenya MuraseShohei Miyazaki
Feb 16, 2008·Neurosurgical Focus·Marcelo D Vilela, David W Newell
Aug 15, 2003·Southern Medical Journal·Andrew R XavierRohit Bakshi
May 13, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Bernd F TomandlSuzanne Fateh-Moghadam
Mar 24, 2012·AJNR. American Journal of Neuroradiology·A J FoxR I Aviv
Mar 1, 2012·Translational Stroke Research·Timothy Q Duong
Mar 1, 2012·Translational Stroke Research·Hsiao-Ying Wey, Timothy Q Duong
Jun 1, 2012·Translational Stroke Research·Guangming ZhuMax Wintermark
Jun 1, 2012·Translational Stroke Research·Weili Lin, William J Powers
Feb 6, 2002·Current Cardiology Reports·Birgitte H Bendixen, Lenore Ocava
Apr 20, 2004·Current Opinion in Neurology·Joseph V GuadagnoJean-Claude Baron
Dec 25, 2008·Expert Review of Cardiovascular Therapy·Reza Hakimelahi, R Gilberto González
Aug 4, 2011·Expert Review of Cardiovascular Therapy·Albert J YooR Gilberto Gonzalez
Apr 23, 2004·Journal of Vascular and Interventional Radiology : JVIR·Jeffery L Sunshine
Jun 7, 2011·Neuroimaging Clinics of North America·Angelos A KonstasMichael H Lev
Jun 7, 2011·Neuroimaging Clinics of North America·Steve H FungPamela W Schaefer
Oct 16, 2010·Academic Radiology·Zhihua SunChunshui Yu
Jun 30, 2009·European Journal of Radiology·Korcan Aysun Gonen, Mehmet Masum Simsek
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vincent DuvalJean Pierre Boissel
Nov 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Emmanuel CarreraJean-Claude Baron
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
Apr 20, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
Jan 30, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Susanne SiemonsenJens Fiehler
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
Dec 17, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shui-Xia ZhangWen-Zhen Zhu

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