Vibrating Sharp-edge Spray Ionization (VSSI) for voltage-free direct analysis of samples using mass spectrometry.

Rapid Communications in Mass Spectrometry : RCM
Xiaojun LiPeng Li

Abstract

The development of miniaturized and field portable mass spectrometers could not succeed without a simple, compact, and robust ionization source. Here we present a voltage-free ionization method, Vibrating Sharp-edge Spray Ionization (VSSI), which can generate a spray of liquid samples using only one standard microscope glass slide to which a piezoelectric transducer is attached. Compared with existing ambient ionization methods, VSSI eliminates the need for a high electric field (~5000 V·cm-1 ) for spray generation, while sharing a similar level of simplicity and flexibility with the simplest direct ionization techniques currently available such as paper spray ionization (PSI) and other solid substrate-based electrospray ionization methods. The VSSI device was fabricated by attaching a piezoelectric transducer onto a standard glass microscope slide using epoxy glue. Liquid sample was aerosolized by either placing a droplet onto the vibrating edge of the glass slide or touching a wet surface with the glass edge. Mass spectrometric detection was achieved by placing the VSSI device 0.5-1 cm from the inlet of the mass spectrometer (Q-Exactive, ThermoScientific). VSSI is demonstrated to ionize a diverse array of chemical species, in...Continue Reading

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Citations

Feb 23, 2019·Journal of the American Society for Mass Spectrometry·Nandhini RanganathanPeng Li
Jan 10, 2019·Rapid Communications in Mass Spectrometry : RCM·Chuping LeeChi-Kung Ni
May 14, 2020·Rapid Communications in Mass Spectrometry : RCM·Sarah TrimpinEllen D Inutan
Apr 6, 2019·Rapid Communications in Mass Spectrometry : RCM·Santosh KarkiCharles N McEwen
Apr 6, 2021·Analytical Chemistry·Junhan WuZheng Ouyang
May 8, 2019·Journal of the American Society for Mass Spectrometry·Sarah TrimpinCharles N McEwen
Aug 29, 2020·Journal of the American Society for Mass Spectrometry·Kinkini Udara JayasundaraStephen J Valentine
Feb 23, 2019·Analytical Chemistry·Clara L FeiderLivia S Eberlin
Dec 4, 2020·Journal of the American Society for Mass Spectrometry·Khoa HoangMilan Pophristic
Dec 19, 2018·Analytical Chemistry·Peng Li, Tony Jun Huang

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