Vibration-controlled transient elastography: a practical approach to the noninvasive assessment of liver fibrosis

Current Opinion in Gastroenterology
Elliot B Tapper, Nezam H Afdhal

Abstract

Therapeutic advances for hepatitis C and the increasing prevalence on nonalcoholic fatty liver disease are reshaping the diagnostic approach to disease staging in clinical hepatology. Well tolerated, inexpensive and reliable alternatives to liver biopsy are a critical need for clinicians and patients alike. Vibration-controlled transient elastography (VCTE, also known as 'transient elastography') is a robust, point-of-care tool for the noninvasive assessment of liver fibrosis. This tool efficiently prioritizes the treatment for patients with viral hepatitis at risk for advanced liver disease and identifies the subgroups with metabolic or cholestatic liver disease who are at the highest risk. Rather than staging fibrosis, VCTE provides an accurate risk estimate of advanced fibrosis. In addition, it is increasingly recognized that elastography can predict outcomes including hepatic decompensation and mortality. The ideal use of this tool is to perform it in conjunction with a serologic marker of fibrosis to confirm its findings. When combined with serologic markers of fibrosis, VCTE allows the vast majority of patients to avoid a liver biopsy.

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Citations

Sep 14, 2018·Canadian Journal of Gastroenterology & Hepatology·Sanda MustapicIvica Grgurevic
Jan 28, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Zhenghui G JiangMichelle Lai

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Methods Mentioned

BETA
biopsy

Software Mentioned

FibroSure
VCTE
HepaScore
FibroScan
EchoSens

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