Vibrational analysis of phosphorothioate DNA: II. The POS group in the model compound dimethyl phosphorothioate [(CH3O)2(POS)]-

Journal of Biomolecular Structure & Dynamics
C A SteinkeV Mohan

Abstract

The results of Raman and Infrared (IR) spectroscopic investigations on the vibrational modes of dimethyl phosphorothioate (DMPS) anion, [(CH3O)2(POS)]-, are reported. Ab initio calculations of the vibrational modes, the IR and Raman spectra and the interatomic force constants of DMPS were performed. A normal mode calculation was performed and the results were used to calculate the potential energy distribution for the vibrational modes. This analysis shows that in DMPS the P-S stretching mode has a frequency of about 630 cm-1 and an angle bending mode involving the sulfur atom has a frequency of about 440 cm-1. The proposed vibrational mode assignments will serve as marker bands in the conformational studies of phosphorothioate oligonucleotides which play a central role in the novel antisense therapeutic paradigm.

References

Jun 1, 1975·Biopolymers·E B Brown, W L Peticolas
Jun 9, 1976·Journal of the American Chemical Society·R L Letsinger, W B Lunsford
Jan 1, 1992·Methods in Enzymology·E Taillandier, J Liquier
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Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S C ErfurthW L Peticolas

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Citations

May 2, 2020·Nucleic Acids Research·Stanley T CrookeXue-Hai Liang
Feb 19, 2021·The Journal of Biological Chemistry·Stanley T CrookeRosanne M Crooke
Aug 18, 2020·Biochemical Pharmacology·Stanley T CrookeRichard S Geary

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