Vibrational imaging of tablets by epi-detected stimulated Raman scattering microscopy

The Analyst
Mikhail N SlipchenkoJi-Xin Cheng

Abstract

Proper chemical imaging tools are critical to the pharmaceutical industry due to growing regulatory demand for intermediate and end-product content uniformity testing. Herein we demonstrate stimulated Raman scattering (SRS) imaging of active pharmaceutical ingredient (API) and four excipients within tablets. Tablets from six manufactures were imaged with a speed of 53 s per frame of 512 × 512 pixels (i.e., 200 μs per pixel) and a lateral spatial resolution as high as 0.62 μm. The SRS chemical imaging was compared to confocal Raman mapping and coherent anti-Stokes Raman scattering (CARS) chemical imaging in terms of speed and chemical selectivity. The acquisition speed of SRS imaging is ca. 10(4) times faster than confocal Raman mapping and SRS technique showed superior to CARS chemical selectivity for studied samples. Our data demonstrate the potential of SRS microscopy in high-speed screening of pharmaceutical solid dosage forms.

References

Aug 18, 1999·Pharmaceutical Research·J BreitenbachJ Neumann
Nov 25, 2003·Analytical Chemistry·Sebastian SchlückerIra W Levin
Apr 20, 2004·Physical Review Letters·Daniel L Marks, Stephen A Boppart
Feb 9, 2005·Physical Review Letters·Stéphane BerciaudBrahim Lounis
Apr 19, 2005·Biophysical Journal·Haifeng WangJi-Xin Cheng
May 19, 2005·Advanced Drug Delivery Reviews·Gabriele Reich
Jan 31, 2006·Optics Letters·Eric O PotmaX Sunney Xie
Mar 17, 2006·The Journal of Physical Chemistry. B·Sang-Hyun LimStephen R Leone
May 9, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Don Clark, Slobodan Sasić
Jun 19, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eunah KangJi-Xin Cheng
Dec 1, 2007·Optics Letters·J X ChengX S Xie
Jan 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A A GowenS E J Bell
Oct 1, 2008·Optics Express·M JurnaH L Offerhaus
Dec 17, 2008·International Journal of Pharmaceutics·Lene Maurer, Hans Leuenberger
Jan 28, 2009·Photochemistry and Photobiology·Tong YeWarren S Warren
May 1, 2009·Analytical Chemistry·Linda Sage
May 9, 2009·The Journal of Physical Chemistry. B·Mikhail N SlipchenkoJi-Xin Cheng
May 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·José Manuel Amigo, Carsten Ravn

❮ Previous
Next ❯

Citations

Feb 16, 2013·Chemical Reviews·Anthony S StenderNing Fang
Mar 19, 2013·Molecular Physics·Fa-Ke LuX Sunney Xie
Dec 4, 2010·Science·Brian G SaarX Sunney Xie
Aug 18, 2010·Journal of Lipid Research·Thuc T LeJi-Xin Cheng
Apr 25, 2012·Annual Review of Analytical Chemistry·Shona StewartPatrick J Treado
Jul 7, 2011·The Journal of Physical Chemistry Letters·Delong ZhangJi-Xin Cheng
Sep 21, 2013·Molecular Pharmaceutics·Frederick G Vogt, Mark Strohmeier
May 21, 2013·Expert Opinion on Drug Delivery·Sergei G Kazarian, Andrew V Ewing
Nov 18, 2014·Expert Opinion on Drug Discovery·Urvi Gala, Harsh Chauhan
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Wing Sin ChiuRichard H Guy
Jan 8, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Patrick S WraySergei G Kazarian
Dec 25, 2010·International Journal of Pharmaceutics·Clare J StrachanHerman L Offerhaus
Oct 31, 2015·Annual Review of Biomedical Engineering·Chi ZhangJi-Xin Cheng
Jul 7, 2015·Advanced Drug Delivery Reviews·Thomas Huser, James Chan
May 12, 2015·Advanced Drug Delivery Reviews·Martin Josef Winterhalder, Andreas Zumbusch
Jul 1, 2011·Laser & Photonics Reviews·Shuhua YueJi-Xin Cheng
Mar 6, 2012·Journal of Biophotonics·Mikhail N SlipchenkoJi-Xin Cheng
Feb 4, 2016·Chemical Society Reviews·W J TippingA N Hulme
Sep 3, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andrew FussellClare Strachan
Sep 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas M SophocleousSteven P Schwendeman
Jul 17, 2013·Analytical Chemistry·Christopher M HartshornMarcus T Cicerone
Jul 16, 2019·Nanoscale Advances·Daniele Di MascoloMarco Francardi
Feb 23, 2021·Frontiers in Pharmacology·Junjie ZengShuhua Yue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.