Vibrio cholerae O1 can assume a chlorine-resistant rugose survival form that is virulent for humans

The Journal of Infectious Diseases
J G MorrisJ A Johnson

Abstract

Vibrio cholerae can shift to a "rugose" colonial morphology associated with expression of an amorphous exopolysaccharide that promotes cell aggregation. Flow cytometric studies indicated that up to 3% of particles in rugose cultures represented aggregates of >5 bacterial cells. Rugose variants of our test strains displayed resistance to killing by chlorine, with viable cells persisting for >30 min in 2 mg/L free chlorine; strains also showed resistance to killing by complement-mediated serum bactericidal activity. Six volunteers fed 10(6) cfu of a rugose variant of V. cholerae O1 El Tor Inaba N16961 developed symptoms typical of cholera, with a mean diarrheal stool volume of 2.2 L (range, 1.4-4.3). Isolates recovered from the stool of infected volunteers retained the rugose phenotype. The data suggest that rugose strains cause human disease. The role of these strains in the epidemiology of cholera remains to be determined.

Citations

Mar 16, 2005·Water Research·Kay Howard, Timothy J J Inglis
Jun 19, 2002·FEMS Microbiology Reviews·Joachim Reidl, Karl E Klose
Oct 22, 2003·FEMS Microbiology Letters·Mohammed H RashidDavid K R Karaolis
Jan 22, 2004·FEMS Microbiology Letters·Mohammed H RashidDavid K R Karaolis
Apr 23, 2003·Microbes and Infection·Thandavarayan RamamurthyGopinath Balakrish Nair
Sep 17, 2009·Nature Reviews. Microbiology·Eric J NelsonAndrew Camilli
Jul 19, 2002·Molecular Microbiology·Adam J Haugo, Paula I Watnick
Jun 23, 2009·Applied and Environmental Microbiology·Heather A O'ConnellEugene W Rice
Oct 9, 2007·Applied and Environmental Microbiology·Weili LiangJorge A Benitez
Dec 26, 2006·Applied and Environmental Microbiology·S K CurtisB D Tall
Sep 26, 2001·Applied and Environmental Microbiology·E Marco-NoalesC Amaro
Aug 30, 2001·Applied and Environmental Microbiology·Y A AnrianyS W Joseph
Oct 31, 2002·Applied and Environmental Microbiology·Afsar AliDavid K R Karaolis
Dec 9, 2003·Applied and Environmental Microbiology·B D TallR C Bayer
Mar 4, 2009·Infection and Immunity·Melissa K Jones, James D Oliver
Sep 19, 2007·Infection and Immunity·Jyl S MatsonVictor J DiRita
Apr 3, 2012·Journal of Bacteriology·Huajun HeDavid M Raskin
Jan 20, 2004·Journal of Bacteriology·Lavin A Joseph, Anita C Wright
Mar 8, 2005·Journal of Clinical Microbiology·Afsar AliJudith A Johnson
Sep 25, 2001·Archives of Disease in Childhood·R M ConroyJ Barnes
Nov 22, 2011·Emerging Infectious Diseases·J Glenn Morris
Jun 21, 1997·Lancet·J L Sánchez, D N Taylor
Nov 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carsten MatzStaffan Kjelleberg
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katharine Kierek, Paula I Watnick
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·F H Yildiz, G K Schoolnik
Oct 7, 2003·Annual Review of Microbiology·Matthew R Parsek, Pradeep K Singh
Aug 27, 2016·Journal of Medical Microbiology·Goutam ChowdhuryThandavarayan Ramamurthy
Jul 2, 2004·Molecular Microbiology·Fitnat H YildizGary K Schoolnik
Sep 7, 2014·Applied and Environmental Microbiology·William H DePasMatthew R Chapman
Oct 1, 2014·Journal of Bacteriology·Tanya L JohnsonMaria Sandkvist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.