Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells

Antioxidants
Małgorzata Zakłos-SzydaAnna Podsędek

Abstract

In recent years, there has been increasing interest in studying food-originated phytocompounds with beneficial influences for humans. Amongst the most active natural substances are polyphenols, for which high content has been identified in the Viburnum opulus berry, and which are unused in Western Europe. Due to its strong antioxidant activity we explored the potential of V. opulus as a preventive agent against diet-related chronic diseases, such as obesity and type 2 diabetes. Among the causes of these ailments is oxidative stress, as well as impaired glucose and free fatty acids (FFA) uptake. Thus, the purpose of this study was to determine biological activity of V. opulus phenolic extracts as cytoprotective agents able to decrease induced oxidative stress, lower lipid accumulation and attenuate glucose and FFA uptake by Caco-2 cells via GLUT2 and CD36/FAT transporters. To determine the source of the most biologically active phenolic compounds, we obtained four phenolic compounds extracts as crude juice, phenolics isolated from juice and two preparations of phenolics obtained with different extraction agents from fruit pomace. Among the studied extracts, the phenolic rich fraction obtained from fruit juice revealed the strong...Continue Reading

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Citations

Jul 16, 2020·International Journal of Molecular Sciences·Małgorzata Zakłos-SzydaAnna Podsędek
Aug 13, 2020·Antioxidants·Kateřina Valentová
Oct 8, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Jolanta Kolińska, Aleksandra Grzelakowska
Feb 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cristina BidianIoana Baldea
Jan 29, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arkadiusz OrchelJanusz Kasperczyk
Nov 11, 2020·Nutrients·Dominika KajszczakAnna Podsędek
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seona ChoTae-Sook Jeong
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Urszula Wójcik-BojekBeata Sadowska
Jun 8, 2021·Life Sciences·Paulo Henrique Evangelista-SilvaElizabethe Adriana Esteves
Jul 31, 2021·Oxidative Medicine and Cellular Longevity·Javad Sharifi-RadWilliam C Cho
Jul 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jolanta Kolińska, Aleksandra Grzelakowska
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Małgorzata Zakłos-SzydaMaria Koziołkiewicz

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Methods Mentioned

BETA
Assay
ELISA
PCR
nuclear translocation
glycosylation

Software Mentioned

Statistica
Excel
GraphPad Prism
TIBCO
OriginPro

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