PMID: 7523894Oct 16, 1994

Vicia faba chromosomal aberration assay

Mutation Research
N KanayaH C Andersson


A collaborative study involving laboratories in six countries was initiated under the sponsorship of the International Programme on Chemical Safety (IPCS) to determine the sensitivity, efficiency and reliability of the Vicia faba root tip meristem chromosomal aberration assay using a standardized protocol. The six laboratories that participated in this study were located in the Slovak Republic, India, Japan, Poland, Sweden and the USA. All laboratories adhered to a standardized protocol for the Vicia faba chromosomal aberration assay. Four coded chemicals, azidoglycerol (AG), N-methyl-N-nitrosourea (MNU), sodium azide (NaN3) and maleic hydrazide (MH) were tested with the Vicia faba chromosomal aberration assay. Of the four chemicals, three (MH, AG and MNU) were found to be clastogenic and gave a concentration related response. However, the results of NaN3 were equivocal which might be explained by the stability of NaN3. The conclusions from this study suggest that the Vicia faba chromosomal aberration bioassay is an efficient and reliable short-term bioassay for the rapid screening of chemicals for clastogenicity.


Jan 1, 1977·Mutation Research·J VeleminskyV Pokorný
Jan 1, 1978·Mutation Research·A KleinhofsR A Nilan
Jan 1, 1978·Mutation Research·Z Swietlińska, J Zuk
Sep 1, 1984·Mutation Research·G E Amphlett, G F Delow
Sep 25, 1956·The Journal of Biophysical and Biochemical Cytology·B A KIHLMAN
Apr 1, 1959·The Journal of Obstetrics and Gynaecology of the British Empire·F J SCANDRETT
Mar 10, 1951·Nature·C D DARLINGTON, J McLENH


Nov 14, 2007·Journal of Applied Genetics·Renata KontekBodgan Kontek
Dec 21, 2006·Environmental Monitoring and Assessment·C V Nageswara RaoS Gulshan
Apr 7, 2004·Mutation Research·Yaroslav IlnytskyyIgor Kovalchuk
Jul 20, 2002·Journal of Ethnopharmacology·Eva MiadokováJaroslav Tóth
Jun 29, 2002·Mutation Research·William F Grant, Elizabeth T Owens
Jul 4, 2012·International Journal of Environmental Research and Public Health·Anita K PatlollaPaul B Tchounwou
Nov 12, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Petr GrúzMasatomi Shimizu
Aug 12, 2014·Ecotoxicology and Environmental Safety·Magdalena Pankiewicz-SperkaGrzegorz Nałęcz-Jawecki
Dec 1, 2010·Environmental Science and Pollution Research International·Sonia ManzoGirolamo Di Francia
Dec 3, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Adrien DhyèvreSylvie Cotelle
Jan 20, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Małgorzata M PosmykRenata Kontek
Jan 22, 2013·Ecotoxicology and Environmental Safety·Daniel Martín Salas-VeizagaEnrique Terrazas-Siles
Jul 21, 2009·The Science of the Total Environment·Mamta KumariNatarajan Chandrasekaran
Dec 26, 2015·Journal of Environmental Sciences (China)·Deepak KumarAmitava Mukherjee
Dec 9, 2015·Ecotoxicology and Environmental Safety·Maria Nilza Corrêa MartinsTatiana da Silva Souza
Aug 8, 2015·Environmental Science and Pollution Research International·Anahí MagdalenoÁngela B Juárez
Mar 22, 2015·Environmental Science and Pollution Research International·A RajeshwariAmitava Mukherjee
Dec 2, 2004·Mutation Research·Paul A White, Larry D Claxton
Jul 21, 2004·Ecotoxicology and Environmental Safety·Kavindra JainShrawan K Gupta
Mar 24, 2004·Environmental Toxicology·Saurabh ChandraS K Gupta
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva MiadokováPeter Rauko
Jan 7, 2020·Environmental Science and Pollution Research International·Simona SchiavoSonia Manzo
Apr 5, 2005·Alternatives to Laboratory Animals : ATLA·Richa SrivastavaShrawan K Gupta
Sep 22, 2018·Environmental Science and Pollution Research International·Mohamed S Youssef, Rabab M Elamawi
Mar 10, 2008·Sensors·Igor Kovalchuk, Olga Kovalchuk
Jan 21, 2021·Environmental Monitoring and Assessment·Adiba KhanPraveen C Verma
Mar 13, 2021·Journal of the Science of Food and Agriculture·Mahmoud M El-SaberAli Osman

Related Concepts

Autosome Abnormalities
Maleic Hydrazide
Mutagenicity Tests
Pharmaceutical Plants
Propylene Glycols

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.