PMID: 7523894Oct 16, 1994

Vicia faba chromosomal aberration assay

Mutation Research
N KanayaH C Andersson

Abstract

A collaborative study involving laboratories in six countries was initiated under the sponsorship of the International Programme on Chemical Safety (IPCS) to determine the sensitivity, efficiency and reliability of the Vicia faba root tip meristem chromosomal aberration assay using a standardized protocol. The six laboratories that participated in this study were located in the Slovak Republic, India, Japan, Poland, Sweden and the USA. All laboratories adhered to a standardized protocol for the Vicia faba chromosomal aberration assay. Four coded chemicals, azidoglycerol (AG), N-methyl-N-nitrosourea (MNU), sodium azide (NaN3) and maleic hydrazide (MH) were tested with the Vicia faba chromosomal aberration assay. Of the four chemicals, three (MH, AG and MNU) were found to be clastogenic and gave a concentration related response. However, the results of NaN3 were equivocal which might be explained by the stability of NaN3. The conclusions from this study suggest that the Vicia faba chromosomal aberration bioassay is an efficient and reliable short-term bioassay for the rapid screening of chemicals for clastogenicity.

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Citations

Nov 14, 2007·Journal of Applied Genetics·Renata KontekBodgan Kontek
Dec 21, 2006·Environmental Monitoring and Assessment·C V Nageswara RaoS Gulshan
Apr 7, 2004·Mutation Research·Yaroslav IlnytskyyIgor Kovalchuk
Jul 20, 2002·Journal of Ethnopharmacology·Eva MiadokováJaroslav Tóth
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Aug 12, 2014·Ecotoxicology and Environmental Safety·Magdalena Pankiewicz-SperkaGrzegorz Nałęcz-Jawecki
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Related Concepts

Azidoglycerol
Azides
Autosome Abnormalities
Treaties
Tachigalia
Maleic Hydrazide
NSC-23909
Mutagenicity Tests
Pharmaceutical Plants
Propylene Glycols

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