Video-assisted mediastinoscopic lymphadenectomy combined with minimally invasive pulmonary resection for left-sided lung cancer: feasibility and clinical impacts on surgical outcomes†

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Ho Jin KimSeung-il Park

Abstract

Although video-assisted mediastinoscopic lymphadenectomy (VAMLA) has greatly increased the accuracy of mediastinal staging, its clinical value as a therapeutic tool for complete mediastinal lymph node dissection in the treatment of left-sided lung cancer is not well elucidated. We identified the consecutive 649 patients with left-sided lung cancer undergoing minimally invasive pulmonary resection between July 2002 and June 2013. Among them, 225 patients underwent VAMLA combined with pulmonary resection (VAMLA + VATS group), while the remaining 424 patients underwent VATS procedure only (VATS group). Operative outcomes including procedural time, removed lymph nodes and node stations, complications and the final pathological mediastinal staging in the both groups were evaluated and compared. There was no significant difference in the baseline profiles between the two groups. The patients in the VATS + VAMLA group showed significantly shorter operative time (116.8 ± 39.8 vs 159.8 ± 44 .0 min; P < 0.001), more extensive lymph node dissection (total number of removed lymph nodes, 29.7 ± 10.8 vs 23.0 ± 8.6; P < 0.001) and the higher rates of patients with mediastinal lymph nodes removed: Station 2 on the right (12.4 vs 0.2%), Station...Continue Reading

References

Feb 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Martin HürtgenPeter Fritz
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yi long WuWei Ou
Jul 5, 2003·The Annals of Thoracic Surgery·Nicolas VenissacJèrôme Mouroux
Aug 5, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gunda LeschberAlbert Linder
Mar 24, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christophe DoddoliPascal Thomas
Feb 16, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Panagiotis MisthosIoannis Skottis
Sep 15, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Didier LardinoisWalter Weder
Oct 6, 2007·Chest·Frank C DetterbeckUNKNOWN American College of Chest Physicians
Dec 19, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Biruta WitteMartin Hürtgen
May 17, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Dong Gon YooSeung-il Park
Dec 17, 2011·General Thoracic and Cardiovascular Surgery·Adnan SayarAtilla Gürses
Apr 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·Sai Yendamuri, Todd L Demmy

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Citations

Jun 5, 2016·Surgical Oncology Clinics of North America·Ziv Gamliel
Aug 28, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ya-Nan WangZhen-Fa Zhang
May 6, 2019·Expert Review of Respiratory Medicine·Hideki UjiieKazuhiro Yasufuku
Mar 17, 2019·Journal of Cancer Research and Clinical Oncology·Likui FangJian Hu

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