Video-assisted thoracoscopic transplantation of myoblasts into the heart

The Annals of Thoracic Surgery
Richard B ThompsonDoris A Taylor

Abstract

Currently, cells are transplanted into injured myocardium either through thoracotomy for open surgical delivery or through catheterization for endoventricular or intracoronary delivery; both methods have limitations. Open surgical delivery limits the potential patient population, whereas catheter-based delivery limits the ability to visualize the injection site and confirm delivery of the cells to the appropriate region. In this study, we examine the feasibility of cell transplantation into myocardium using a minimally invasive thoracoscopic approach. Seven swine underwent thoracoscopic cell transplantation. Using a prototype injection device, approximately 10 million myoblasts were injected into the anterior, lateral, posterior, and apical regions of myocardium. Animals were recovered up to 7 days, and after euthanasia, hearts were explanted for histology. All seven swine had successful delivery of myoblasts into the defined injection sites, as confirmed by analysis of an operative video, magnetic resonance imaging of iron-oxide-labeled cells, and histologic examination. Thoracoscopic cellular cardiomyoplasty is feasible and allows the surgeon the benefits of direct visualization of the cell injection while minimizing morbidit...Continue Reading

References

Feb 24, 2001·Lancet·P MenaschéJ P Marolleau
Jul 5, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Nabil DibDoris A Taylor
Feb 27, 2003·Pediatric Transplantation·Donald OrlicPiero Anversa
May 24, 2006·The Journal of Surgical Research·Sitaram M EmaniDoris A Taylor

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Citations

Oct 21, 2005·Basic Research in Cardiology·H C OttD A Taylor
Aug 13, 2009·European Radiology·Monique R BernsenGabriel P Krestin
May 26, 2007·Journal of Interventional Cardiology·Juan C ChachquesAlain F Carpentier
Oct 27, 2009·The Annals of Thoracic Surgery·Jeremy L HerrmannDaniel R Meldrum
Aug 23, 2005·Asian Cardiovascular & Thoracic Annals·Juan C ChachquesAlain Carpentier

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