Videocapillaroscopy of the Oral Mucosa in Patients with Diabetic Foot: Possible Diagnostic Role of Microangiopathic Damage?

Journal of Clinical Medicine
Giuseppe A ScardinaPietro Messina

Abstract

Diabetic foot represents one of the most serious and expensive complications of diabetes and is subject to a high percentage of amputations that are almost always preceded by ulcers ascribable to neuropathy and/or vasculopathy. Videocapillaroscopy (VCS) can be a valuable aid in order to uncover morpho-structural anomalies in the vascular bed, both at the level of the oral mucosa and at the level of the terminal vessels of the lower limb. Sixty subjects divided into 4 groups were enrolled: 15 healthy subjects; 15 patients with diabetes for more than 10 years without ulcerative foot lesions; 15 patients with neuropathic diabetic foot (clinical diagnosis, MDNS); 15 patients with ischemic diabetic foot (clinical diagnosis, ABI, lower limb doppler). A complete videocapillaroscopic mapping of the oral mucosa was carried out on each patient. The areas investigated were: labial mucosa, the retro-commissural region of the buccal mucosa, and the vestibular masticatory mucosa (II and V sextant). The analysis of the morphological and densitometric characteristics of the capillaries revealed the following: a significant reduction in capillary density in neuropathic (mean ± SD 7.32 ± 2.1) and ischemic patients (mean ± SD 4.32 ± 3.2) compared...Continue Reading

References

Nov 13, 2003·Current Diabetes Reports·Chantel Hile, Aristidis Veves
Jul 19, 2005·Current Pharmaceutical Design·T Dinh, A Veves
Jul 11, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Kenichi OgawaKishio Nanjo
Mar 28, 2009·Journal of Oral Science·Giuseppe A ScardinaPietro Messina
Feb 2, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giuseppe Alessandro ScardinaPietro Messina
May 20, 2015·Diabetes & Metabolic Syndrome·Saba NoorJamal Ahmad
Oct 13, 2015·Diabetes/metabolism Research and Reviews·Frances Game
Sep 12, 2017·International Journal of Clinical Practice·Nicholas D BarwellUNKNOWN Scottish Diabetes Foot Action Group
Nov 14, 2017·Journal of Diabetes Research·I MigdalisP Valensi
Nov 18, 2017·BMJ : British Medical Journal·Satish Chandra MishraAbha Mehndiratta
Nov 28, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giuseppe ScardinaPietro Messina
Mar 7, 2018·Current Pharmaceutical Design·Onno A MennesWiendelt Steenbergen
Mar 17, 2018·Annales d'endocrinologie·Huidi TcheroEmmanuel Rusch
Jan 9, 2019·JAMA : the Journal of the American Medical Association·Dara Grennan
Jan 31, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giuseppe A ScardinaPietro Messina
May 10, 2019·Physiological Measurement·O A MennesW Steenbergen
Dec 18, 2019·Diabetes/metabolism Research and Reviews·Sanjeev SharmaGerry Rayman
Jan 4, 2020·Microvascular Research·Patricia P WadowskiBernd Jilma
Feb 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Adam Behroozian, Joshua A Beckman

❮ Previous
Next ❯

Citations

Jul 12, 2021·Microvascular Research·Dogukan Yilmaz, Ayfer Altas

❮ Previous
Next ❯

Methods Mentioned

BETA
amputations
amputation

Software Mentioned

Open Office
VideoCap
PAST
VCS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.