Videofluoroscopic swallow study features of lower esophageal sphincter achalasia-like syndrome in dogs

Journal of Veterinary Internal Medicine
Megan E GrobmanCarol R Reinero

Abstract

Megaesophagus (ME) carries a poor long-term prognosis in dogs. In people, lower esophageal sphincter (LES) disorders causing functional obstruction are rare causes of ME that may respond to targeted treatment. Functional LES disorders are reported rarely in dogs because of challenges in diagnostic methodologies. To identify dogs with videofluoroscopic swallow study (VFSS) features of LES achalasia-like syndrome (LES-AS). We hypothesized that dogs with LES-AS could be distinguished from normal dogs using standardized VFSS criteria. Dogs with LES-AS by VFSS (n = 19), healthy normal dogs (n = 20). Retrospective study. One-hundred thirty dogs presented to the University of Missouri Veterinary Health Center (MU-VHC) between April 2015 and December 2017 for a free-feeding VFSS; 20 healthy dogs were included as controls. Swallow studies were evaluated for failure of the LES to relax during pharyngeal swallow (LES-AS). Affected dogs subsequently were evaluated using standardized criteria to identify metrics important for identifying and characterizing dogs with LES-AS. Nineteen dogs with LES-AS were identified out of 130 VFSS. Megaesophagus was present in 14 of 19 (73.7%) dogs with LES-AS. A baseline esophageal fluid-line and "bird bea...Continue Reading

References

Jan 1, 1997·Scandinavian Journal of Infectious Diseases·T Heiskanen-KosmaK Heinonen
Oct 27, 2007·Neurosurgical Focus·Jason RockhillMarc C Chamberlain
Jun 16, 2011·Journal of the American Veterinary Medical Association·Alix R McBreartyRory Bell
Jan 25, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Boeckxstaens, G Zaninotto
Jan 23, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C P GyawaliM F Vaezi
May 15, 2013·Journal of Neurogastroenterology and Motility·Zafar NeyazUday C Ghoshal
May 31, 2013·American Journal of Veterinary Research·Jennifer KempfPeter H Kook
Jan 1, 2012·ISRN Veterinary Science·Rachel E Pollard
Aug 27, 2013·Gastroenterology·Peter J Kahrilas, Guy Boeckxstaens
Mar 13, 2014·Journal of Veterinary Internal Medicine·J KempfP H Kook
Dec 23, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C P Gyawali
Sep 28, 2016·World Journal of Gastroenterology : WJG·Janette Furuzawa-CarballedaGonzalo Torres-Villalobos
Oct 30, 2016·Journal of Neurogastroenterology and Motility·Da Hyun Jung, Hyojin Park
Feb 28, 2017·Journal of Veterinary Internal Medicine·R A HarrisT E Lever
Mar 25, 2017·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Rachel E PollardCecily M Bonadio
Apr 21, 2017·Current Opinion in Gastroenterology·Peter J Kahrilas, John E Pandolfino
Apr 7, 2018·Nature Reviews. Gastroenterology & Hepatology·Peter J KahrilasUNKNOWN International Working Group for Disorders of Gastrointestinal Motility and Function

❮ Previous
Next ❯

Citations

Nov 3, 2020·The Veterinary Clinics of North America. Small Animal Practice·Megan Grobman

❮ Previous
Next ❯

Methods Mentioned

BETA
motility studies

Software Mentioned

MedCalc
VFSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.