Videofluoroscopic Validation of a Translational Murine Model of Presbyphagia

Dysphagia
Teresa E LeverKate L Robbins

Abstract

Presbyphagia affects approximately 40% of otherwise healthy people over 60 years of age. Hence, it is a condition of primary aging rather than a consequence of primary disease. This distinction warrants systematic investigations to understand the causal mechanisms of aging versus disease specifically on the structure and function of the swallowing mechanism. Toward this goal, we have been studying healthy aging C57BL/6 mice (also called B6), the most popular laboratory rodent for biomedical research. The goal of this study was to validate this strain as a model of presbyphagia for translational research purposes. We tested two age groups of B6 mice: young (4-7 months; n = 16) and old (18-21 months; n = 11). Mice underwent a freely behaving videofluoroscopic swallow study (VFSS) protocol developed in our lab. VFSS videos (recorded at 30 frames per second) were analyzed frame-by-frame to quantify 15 swallow metrics. Six of the 15 swallow metrics were significantly different between young and old mice. Compared to young mice, old mice had significantly longer pharyngeal and esophageal transit times (p = 0.038 and p = 0.022, respectively), swallowed larger boluses (p = 0.032), and had a significantly higher percentage of ineffectiv...Continue Reading

References

Sep 1, 1992·Gastroenterology·J RobbinsG B Kempster
Mar 1, 1992·The Journal of Experimental Zoology·R Z GermanA J Thexton
Jun 1, 1991·AJR. American Journal of Roentgenology·O Ekberg, M J Feinberg
Nov 1, 1966·American Zoologist·J P Scott
Oct 1, 1993·Archives of Physical Medicine and Rehabilitation·C L LazarusA Halper
Mar 21, 1998·The Journal of Experimental Zoology·A J ThextonR Z German
Sep 14, 1999·Clinical Radiology·Y A Aly, H Abdel-Aty
Mar 1, 1964·Radiology·F F ZBORALSKEK H SOERGEL
Jul 1, 1964·The Journal of Clinical Investigation·K H SOERGELJ R AMBERG
Jul 28, 2004·Physiology & Behavior·T C Carvalho, G E Gerstner
Feb 25, 2005·Histochemistry and Cell Biology·Jürgen Wörl, Winfried L Neuhuber
Apr 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paula LeslieJanet A Wilson
Jun 4, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mineka YoshikawaTeruki Komatsu
Nov 23, 2006·Seminars in Speech and Language·Stephanie Kays, JoAnne Robbins
Apr 13, 2007·The Laryngoscope·Nelson RoyLisa Thomas
Jul 24, 2007·Best Practice & Research. Clinical Gastroenterology·Jeri A Logemann
Sep 13, 2007·The Annals of Otology, Rhinology, and Laryngology·Wael M AbdelkafyMichael M Johns
Oct 4, 2008·Journal of Applied Physiology·Anurag AgrawalIndu Parikh
Oct 23, 2008·Physical Medicine and Rehabilitation Clinics of North America·Bonnie Martin-Harris, Bronwyn Jones
Oct 23, 2008·Physical Medicine and Rehabilitation Clinics of North America·Ianessa A Humbert, Joanne Robbins
Nov 18, 2008·NeuroImage·Ianessa A HumbertJoanne Robbins
Dec 25, 2008·Dysphagia·Teresa E LeverAlexander K Murashov
Mar 31, 2009·The Annals of Otology, Rhinology, and Laryngology·Susan G ButlerShannon Kemp
Apr 21, 2009·The Annals of Otology, Rhinology, and Laryngology·Susan G ButlerCatherine Rees
Jun 2, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Denise M NeyJoAnne Robbins
Jun 6, 2009·Dysphagia·Teresa E LeverAlexander K Murashov
Apr 5, 2011·Behavioural Brain Research·Michelle R CiucciNadine P Connor
May 21, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J A Logemann, K Larsen
Nov 15, 2011·The Laryngoscope·Susan G ButlerStephen B Kritchevsky
Nov 24, 2012·Nucleic Acids Research·Carol J BultUNKNOWN Mouse Genome Database Group
Jun 8, 2013·Brazilian Journal of Otorhinolaryngology·Fabiana Gonçalez D'OttavianoMaria Sheila Guimarães Rocha
Aug 3, 2013·Dysphagia·Naoto SugiyamaAkane Yuki
Apr 3, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Leslie A ShockTeresa E Lever
Apr 14, 2015·Journal of Visualized Experiments : JoVE·Teresa E LeverMollie A Ulsas

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Citations

Sep 13, 2019·The Journal of Comparative Neurology·Megan M HaneyTeresa E Lever
Feb 23, 2020·Frontiers in Neurology·Lauren WelbyTeresa E Lever
Apr 7, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cameron J HinkelTeresa E Lever
Jan 31, 2017·Dysphagia·Rebecca Z GermanAllan J Thexton
May 1, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Megan M HaneyTeresa E Lever
Sep 27, 2019·Frontiers in Neuroscience·Tiffany J GlassNadine P Connor
Feb 26, 2020·The Laryngoscope·Lauren WelbyTeresa E Lever
May 2, 2018·Parkinson's Disease·François D H GouldJason R Richardson
Sep 22, 2017·Scientific Reports·Hiroshi KidaToyojiro Matsuishi
Jan 2, 2019·Laryngoscope Investigative Otolaryngology·Andrew M Vahabzadeh-HaghJennifer L Long
Jul 4, 2018·Scientific Reports·Yalda MoayediEllen A Lumpkin
Oct 6, 2020·Experimental Gerontology·Heidi KletzienNadine P Connor

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