Videolaparoscopic microwave ablation in patients with HCC at a European high-volume center: Results of 815 procedures

Journal of Surgical Oncology
Umberto CilloCamillo Aliberti

Abstract

Videolaparoscopic (VL) microwave ablation (MWA) is not included in most of the international guidelines as a therapeutic option for hepatocellular carcinoma (HCC). Aim of this study was to assess the safety of VL MWA in patients with HCC for whom resection or percutaneous ablation is unsuitable. A retrospective analysis was performed on a prospective database of patients with HCC treated with VL MWA at our institution from 2009 to 2016. Patient demographics, operational characteristics, and complications were recorded. Statistical analysis was performed to identify safety profile, overall survival and recurrence rate. A total of 815 VL MWA were performed in 674 patients with a mean age of 64 years. Patients had a mean Model for End-stage Liver Disease score of 10 (±3); 32.8% were Child B, 44.1% Barcelona Clinic Liver Cancer B-C. Perioperative mortality was 0.4%. Overall morbidity was 30.8%, with Dindo-Clavien complications ≥3 in 2%. The median length of stay was 2 days. In 43.1% VL MWA was the first-line therapy. Overall 1-, 3-, and 5-year survival rates were 81.9%, 54.9%, and 35.9%. The present is the largest series of VL ablation and the bigger number of patients with HCC treated with MW reported nowadays. It confirms the saf...Continue Reading

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Citations

Aug 19, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Roberto SantambrogioMarco Antonio Zappa
Jul 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Henrik PetrowskyPierre-Alain Clavien
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Apr 6, 2021·Frontiers in Surgery·Umberto CilloFrancesco D'Amico
Jun 3, 2021·Langenbeck's Archives of Surgery·Luís Filipe Abreu de CarvalhoFrederik Berrevoet

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