View Point: Disease Modification and Cell Secretome Based Approaches in Parkinson's Disease: Are We on the Right Track?

Biologics : Targets & Therapy
Thomas Müller


The term idiopathic Parkinson's disease describes an entity of various not well-characterized disorders resembling each other. They are characterized by chronic neuronal dying originating from various disease mechanisms. They result in the onset of motor and related non-motor features, both of which respond to administration of personalized drug combinations and surgical therapies. The unmet need is beneficial disease course modification with repair and neurogenesis. Objectives are to discuss the value of cell secretome based treatments including neuronal graft transplantation and to suggest as an alternative the stimulation of an endogenous available approach for neuronal repair. Chronic neurodegenerative processes result from different heterogeneous, but complementing metabolic, pathological cascade sequences. Accumulated evidence from experimental research suggested neuron transplantation, stem cell application and cell secretome-based therapies as a promising future treatment with cure as an ultimate goal. To date, clinical testing of disease-modifying treatments has focused on substitution or repair of the remaining dopamine synthesizing neurons following diagnosis. At diagnosis, many of the still surviving and functioning...Continue Reading


Feb 13, 1969·The New England Journal of Medicine·G C CotziasR Gellene
Jan 1, 1997·Reviews in the Neurosciences·W KuhnD Poehlau
Jul 3, 2003·Annals of Neurology·Alan L WhoneUNKNOWN REAL-PET Study Group
Feb 10, 2004·Journal of Neural Transmission·H PrzuntekP Riederer
Jun 25, 2005·The Journal of Biological Chemistry·Jodie L BabittHerbert Y Lin
Apr 9, 2008·Nature Medicine·Jeffrey H KordowerC Warren Olanow
Jun 11, 2008·Archives of Neurology·William J Weiner
Jan 30, 2010·Parkinsonism & Related Disorders·William J Weiner
Jun 3, 2010·Annals of Neurology·Hsiao-Chun ChengRobert E Burke
May 24, 2011·Neurobiology of Disease·Jeffrey H KordowerTimothy J Collier
May 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Marios PolitisPaola Piccini
Oct 15, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Curt R FreedRobert E Breeze
Dec 21, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Takekazu KuboToshihide Yamashita
May 10, 2012·Cell Adhesion & Migration·Brian Key, Grace J Lah
Jun 2, 2012·Expert Review of Neurotherapeutics·Glenda HallidayClaire Shepherd
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beate WinnerFred H Gage
Dec 1, 2012·Progress in Brain Research·Marios Politis, Paola Piccini
Aug 31, 2013·Genetic Testing and Molecular Biomarkers·Xiaowei LiuZhi Liu
Aug 7, 2014·Journal of Alzheimer's Disease : JAD·Pravir KumarRashmi K Ambasta
Aug 29, 2014·Stem Cells International·Gregory E TullisMark D Kirk
Mar 25, 2015·CNS & Neurological Disorders Drug Targets·Jeswinder Sian-HulsmannPeter Riederer
Jul 3, 2015·Frontiers in Neuroscience·Mary GannonQin Wang
Jul 4, 2015·Annals of Medicine·Oscar E SimonsonSergey Rodin
Aug 19, 2016·Frontiers in Pharmacology·Ana MaroteAntónio J Salgado

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Trends in Biotechnology
Leila DaneshmandiCato T Laurencin
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Catriona J CunninghamStuart M Allan
© 2021 Meta ULC. All rights reserved