PMID: 11310667DOI: 10.1248/cpb.49.413Apr 20, 2001Paper
Viewing of complex molecules of ethidium bromide and plasmid DNA in solution by atomic force microscopy
Chemical & Pharmaceutical Bulletin
K UtsunoT Iwamoto
Abstract
Tertiary structure changes in plasmid DNA, induced by ethidium bromide intercalation, have been observed in aqueous solutions by the use of an atomic force microscope. A relaxed closed circular pBR322 molecule became a positively supercoiled complex on the drug binding. The supercoiling always resulted in an interwound (or a plectonemic) form, but never a solenoidal (or a toroidal) form. A quantitative analysis of the compactness of such supercoiled complexes has been carried out.
References
Jan 14, 1992·Biochemistry·C BustamanteR Keller
Jun 25, 1974·Journal of Molecular Biology·J D McGhee, P H von Hippel
Dec 1, 1994·Biophysical Journal·M BezanillaH G Hansma
Jan 21, 1994·Journal of Molecular Biology·J BednarA D Bates
Aug 2, 1996·Journal of Molecular Biology·P J HeathJ M Schurr
Apr 1, 1996·Biophysical Journal·H G Hansma, D E Laney
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E CouryL A Bottomley
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y L Lyubchenko, L S Shlyakhtenko
May 1, 1997·Nucleic Acids Research·K RippeJ Langowski
Nov 14, 1997·Chemical & Pharmaceutical Bulletin·K Utsuno, M Tsuboi
Jul 7, 1998·Journal of Molecular Biology·L S ShlyakhtenkoY L Lyubchenko
Dec 10, 1998·Chemical & Pharmaceutical Bulletin·K UtsunoM Tsuboi
Jul 2, 1999·Biophysical Journal·L S ShlyakhtenkoY L Lyubchenko
Dec 20, 1999·Chemical & Pharmaceutical Bulletin·K UtsunoM Tsuboi
Jul 8, 2000·Journal of Microscopy·L H PopeP M Williams
❮ Previous
Next ❯
Citations
Nov 13, 2004·European Biophysics Journal : EBJ·Olivier PiétrementEric Le Cam
Jun 28, 2002·Nucleic Acids Research·Torunn BergeRobert M Henderson
Feb 19, 2002·Chemical & Pharmaceutical Bulletin·Kuniharu UtsunoToschitake Iwamoto
Apr 6, 2006·Chemical & Pharmaceutical Bulletin·Yangzhe WuYong Chen
Jan 5, 2010·Chemical & Pharmaceutical Bulletin·Shinichi YoshikawaMitsuhiro Takeshita
Jul 19, 2011·Analytical and Bioanalytical Chemistry·Marek MahutWolfgang Lindner
Mar 20, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Naoko KidaKenichi Yoshikawa
Dec 10, 2015·European Biophysics Journal : EBJ·M KopaczynskaJ H Fuhrhop
Jul 8, 2008·Biochemical and Biophysical Research Communications·Jia YuXitai Huang
Oct 9, 2007·Advanced Drug Delivery Reviews·Ya Tsz A TurnerMartyn C Davies
Dec 14, 2004·Journal of Molecular Biology·Yolanda D TsengRobert M Henderson
Feb 5, 2003·Biochemical and Biophysical Research Communications·Miriam ArgamanEsther Priel
Dec 4, 2004·Biopolymers·David PastréEric Le Cam
May 3, 2013·Cell Biochemistry and Biophysics·Samrat DuttaMartin Guthold
Oct 12, 2016·Chemical & Pharmaceutical Bulletin·Kuniharu UtsunoHasan Uludağ
Nov 4, 2017·Inorganic Chemistry·Ma Ángeles MartínezFélix A Jalón
❮ Previous
Next ❯
Related Concepts
Related Feeds
AFM in situ DNA
AFM in situ DNA describes in situ analysis (or study) of DNA using atomic force microscopy. Discover the latest research on AFM in situ DNA here.
Related Papers
Journal of Microscopy
L H PopePhilip M Williams
Biochemistry
C BustamanteR Keller
Proceedings of the National Academy of Sciences of the United States of America
Y L Lyubchenko, L S Shlyakhtenko
Nucleic Acids Research
Y L LyubchenkoS Adhya