Viewpoint: Origin of SARS-CoV-2

Kenneth LundstromAdam M Brufsky


The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational "hot spot" as only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted dur...Continue Reading


Jan 1, 1989·Viral Immunology·M G Rossmann
Oct 8, 2016·Advances in Virus Research·R J G HulswitB-J Bosch
Feb 15, 2020·Emerging Microbes & Infections·Chuan XiaoFeng Gao
Mar 21, 2020·Current Biology : CB·Tao ZhangZhigang Zhang
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 21, 2020·Journal of Medical Virology·Adam Brufsky
Jun 27, 2020·BioRxiv : the Preprint Server for Biology·Lizhou ZhangHyeryun Choe
Jul 11, 2020·Nature Structural & Molecular Biology·Antoni G WrobelSteven J Gamblin
Sep 4, 2020·Journal of Medical Virology·Murat SeyranAdam M Brufsky

❮ Previous
Next ❯


Feb 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Annoor AwadasseidWen Zhang
Mar 10, 2021·International Journal of Health Services : Planning, Administration, Evaluation·Seyed A NejadghaderiNima Rezaei
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Apr 3, 2021·Archives of Gynecology and Obstetrics·Mona MirbeykNima Rezaei
May 3, 2021·Journal of Neuroimmunology·Homa PourriyahiNima Rezaei
Jul 31, 2021·Environmental Research·Jose L Domingo
Aug 6, 2021·The Cochrane Database of Systematic Reviews·Kelly AnsemsFalk Fichtner

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
R. AhmedMd. Shahidul Islam
Alejandro Flores-AlanisRosario Morales-Espinosa
Alejandro Flores-AlanisRosario Morales-Espinosa
Alejandro Flores-AlanisRosario Morales-Espinosa
© 2021 Meta ULC. All rights reserved