Viewpoint: Origin of SARS-CoV-2

Viruses
Kenneth LundstromAdam M Brufsky

Abstract

The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational "hot spot" as only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted dur...Continue Reading

References

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Feb 15, 2020·Emerging Microbes & Infections·Chuan XiaoFeng Gao
Mar 21, 2020·Current Biology : CB·Tao ZhangZhigang Zhang
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Apr 21, 2020·Journal of Medical Virology·Adam Brufsky
Jun 27, 2020·BioRxiv : the Preprint Server for Biology·Lizhou ZhangHyeryun Choe
Jul 11, 2020·Nature Structural & Molecular Biology·Antoni G WrobelSteven J Gamblin
Sep 4, 2020·Journal of Medical Virology·Murat SeyranAdam M Brufsky

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Citations

Feb 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Annoor AwadasseidWen Zhang
Mar 10, 2021·International Journal of Health Services : Planning, Administration, Evaluation·Seyed A NejadghaderiNima Rezaei
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Apr 3, 2021·Archives of Gynecology and Obstetrics·Mona MirbeykNima Rezaei
May 3, 2021·Journal of Neuroimmunology·Homa PourriyahiNima Rezaei
Jul 31, 2021·Environmental Research·Jose L Domingo
Aug 6, 2021·The Cochrane Database of Systematic Reviews·Kelly AnsemsFalk Fichtner

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