Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T-cell and B-cell lymphoproliferative disorders

Journal of Cutaneous Pathology
Nneka ComfereBrian Swick

Abstract

Appropriate use criteria have been developed for many tests using expert judgment, evidence-based practice and clinical experience. In this context, we report the opinions of practitioners about clonality assays in various clinical scenarios where cutaneous lymphoma is suspected. An Appropriate Use Criteria Task Force sponsored by the American Society of Dermatopathology (ASDP) synthesized clinical scenarios for cutaneous lymphoproliferative disorders (LPDs). We conducted, summarized and presented a relevant literature search to an audience of 144 dermatopathologists with a variety of practice experiences at the 53rd Annual Meeting of the ASDP in Chicago, IL. Twenty-seven clinical scenarios for LPDs (13 T-cell and 14 B-cell) were defined. Forty relevant studies for T-cell receptor gene clonality assays and 20 relevant studies for IgH/IgK clonality assays were identified. Audience response data from participating dermatopathologists reflected a wide variety of approaches to the application of clonality assays in the evaluation of LPDs, based on practice setting, personal experience and test availability. Our clinical scenario analysis and literature review revealed well-supported clinical scenarios and identified opportunities f...Continue Reading

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Citations

Feb 14, 2018·Journal of Cutaneous Pathology·Kristin TorreMichael Murphy
Mar 8, 2019·European Journal of Haematology·Anna L PatersonHesham ElDaly
Apr 17, 2019·Journal of Cutaneous Pathology·Huma ShamimNneka Comfere
Feb 11, 2020·Frontiers in Oncology·Ritika Walia, Cecilia C S Yeung
Jan 23, 2021·The American Journal of Dermatopathology·Emily Symes, Nicole Dominiak

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