Villoglandular adenocarcinoma of the vulva

Gynecologic Oncology
A RodriguezF F Nogales

Abstract

Only two previous cases of villoglandular adenocarcinoma of the vulva, an entity morphologically similar to tumors found in the uterine cervix and colorectum, have been reported. This paper communicates the first complete immunohistochemical study in villoglandular adenocarcinoma in order to determine its phenotype and histogenesis. A 69-year-old woman had a 1.5-cm nodule in the right labium majus. Histologically, it corresponded to a minimally atypical, villoglandular adenocarcinoma with a small microinvasion. Immunohistochemically, it was positive to OC125, CEA, and OC19.9 and coexpressed cytokeratins 7 and 20. Chromogranin, nuclear estrogen, and progesterone receptors were negative. Phenotypic expression was more consistent with a papillary mucinous ovarian or cervical neoplasm than of a colonic one. Its behavior was similar to that of its morphologic counterpart in the cervix, since the patient had no recurrence 3 years after a wide local excision.

References

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Citations

Feb 11, 2016·Pathology, Research and Practice·M H J van RosmalenJ M J Piek
Aug 2, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alina NicolaeFrancisco F Nogales
Jul 11, 2006·Journal of Lower Genital Tract Disease·Valérie DubéTerence J Colgan
Aug 10, 2017·Obstetrics & Gynecology Science·In Ho LeeKi Heon Lee
Jun 1, 2019·International Cancer Conference Journal·Tomoko KuritaToru Hachisuga
May 16, 2017·Case Reports in Pathology·Akiko MatsuzakiNaoki Yoshimi
Oct 10, 2020·Seminars in Diagnostic Pathology·Mohamed Mokhtar Desouki, Oluwole Fadare
Jun 28, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Juan B Laforga, Javier Martin
Aug 13, 2021·Gynecologic Oncology Reports·Javier Martín-VallejoPedro A Clemente-Pérez

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