PMID: 8971557Dec 1, 1996Paper

Vimentin-positive adenocarcinomas of the stomach: co-expression of vimentin and cytokeratin

Histopathology
T UtsunomiyaM Tsuneyoshi

Abstract

Recently, the expression of vimentin has been reported in some carcinomas. This study was designed to clarify the significance of vimentin expression in solid type poorly differentiated adenocarcinomas of the stomach. Immunohistochemically, 239 poorly differentiated adenocarcinomas with solid components of the stomach were stained for vimentin. Vimentin-positive cases were also stained by CAM 5.2 using serial mirror sections. We found 15(6.3%) vimentin-positive cases. Twelve of them demonstrated varying amounts of rhabdoid-like cells. Eight cases diffusely co-expressed vimentin and cytokeratin simultaneously. In addition, four co-expressing cases showed positive staining with Keratin-903 which recognizes the high molecular-weight cytokeratin. Most of the co-expressing cases showed a diffuse proliferation of polygonal tumour cells with focal cell-to-cell contact. The prognosis of the co-expressing cases was poor in comparison with that of the 89 vimentin-negative tumours (P < 0.05).

Citations

Mar 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kohei ShomoriHisao Ito
May 4, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Maria Rosaria RaspolliniGregor Mikuz
Apr 2, 2010·Annals of Surgical Oncology·Masaaki IwatsukiMasaki Mori
Aug 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Natalia YanchenkoTakanori Hattori
Jan 13, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Sonal SharmaMrinalini Kotru
Jun 12, 2013·Clinical and Translational Science·Wenwen ZhaoWensheng Qiu
Oct 23, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A MirzaS Pritchard
Mar 23, 2001·Pathology, Research and Practice·A M NogueiraM Sobrinho-Simões
Aug 9, 2001·International Journal of Surgical Pathology·Yumi OshiroMasazumi Tsuneyoshi
Jan 17, 2004·The American Journal of Dermatopathology·Bernhard Zelger
Feb 9, 2018·Clinical Journal of Gastroenterology·Shogo KawaguchiShinsaku Fukuda
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y OshiroM Tsuneyoshi

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