PMID: 6537922Feb 1, 1984Paper

Vinblastine-induced autophagocytosis: the effect of disorganization of microfilaments by cytochalasin B

Experimental and Molecular Pathology
Y Hirsimäki, P Hirsimäki

Abstract

The effects of disorganization of cellular microfilaments by cytochalasin B on vinblastine-induced autophagocytosis was studied in Ehrlich ascites tumor cells in vitro. Incubation with vinblastine induced a formation of autophagic vacuoles in the cytoplasm. The disorganization of microfilaments by cytochalasin B failed to inhibit vinblastine-induced autophagocytosis. Incubation with cytochalasin B alone induced a rapid formation of blebs on the cell surface. These contained cytoplasmic organelles and were connected by a narrow shaft to the main part of the cell. Thin subcortical microfilaments seen in the control cell cytoplasm were apparently relocated after cytochalasin B treatment and formed amorphous masses deeper in the cytoplasm. Vinblastine did not affect the formation of blebs after cytochalasin B treatment.

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Citations

Sep 15, 1985·Experientia·B Grinde
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Miettinen, H Reunanen
Dec 23, 2015·Future Medicinal Chemistry·Abigail R Solitro, Jeffrey P MacKeigan
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Sep 11, 1992·Journal of Cellular Physiology·A AplinW A Dunn

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