PMID: 7201395Feb 1, 1982Paper

Vinblastine, Vincristine and Vindesine: anti-invasive effect on MO4 mouse fibrosarcoma cells in vitro

European Journal of Cancer & Clinical Oncology
M M MareelR M Van Cauwenberge

Abstract

Inhibition of the invasiveness of MO4 mouse fibrosarcoma cells by the vinca alkaloid, vinblastine (VLB), vincristine (VCR) and vindesine (VDS), has been examined in vitro. At doses between 0.006 microgram/ml (minimal effect) and 0.1 microgram/ml (complete inhibition) these drugs interfered with the invasion of MO4 cells from an aggregate confronting a fragment of embryonic chick heart in three-dimensional culture. We have also examined the effect of these drugs on the following activities of MO4 cells: growth, directional migration and assembly of the cytoplasmic microtubule complex. Growth and directional migration were affected by the same doses of vinca alkaloids as invasion. In contrast with the vinca alkaloids, 5-fluorouracil at 1 microgram/ml inhibited growth but allowed directional migration and invasion. At a dose of 0.3 microgram/ml VLB, VCR and VDS interfered with the assembly of cytoplasmic microtubules, as visible after immunocytochemical staining with tubulin antiserum. Ultrastructural analysis demonstrated that inhibition of invasion in three-dimensional culture corresponds with abolishment of the cytoplasmic microtubule complex. Anti-invasive concentrations of VLB, VCR and VDS represent clinically achievable plas...Continue Reading

References

Nov 1, 1979·Cell Biology International Reports·M M Mareel
Oct 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J WellsA H Laing
Feb 1, 1976·Journal of the National Cancer Institute·M De BrabanderJ Hoebeke
Apr 4, 1973·Nature: New Biology·I J Fidler
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M M MareelG Storme
Sep 1, 1980·Cancer Treatment Reviews·B T Hill, R D Whelan

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Citations

Jan 1, 1986·Cancer Metastasis Reviews·R G Greig, D L Trainer
Jan 1, 1983·Clinical & Experimental Metastasis·C MeyvischM M Mareel
Apr 1, 1985·Clinical & Experimental Metastasis·W J de NeveM M Mareel
Mar 1, 1988·Clinical & Experimental Metastasis·E PrangeH Pralle
Oct 13, 2007·Clinical & Experimental Metastasis·Walter RhombergChristoph H Saely
Jan 5, 2013·Toxicology·Xavier TekpliDominique Lagadic-Gossmann
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. ElliottM. Jones
Nov 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Walter RhombergRichard Pötter

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