PMID: 9655358Jul 9, 1998Paper

Vincristine and focal segmental sclerosis: do we need a multicentre trial?

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
C D GoonasekeraM J Dillon

Abstract

Over the last 10 years, eight children have received vincristine for the treatment of steroid- and cyclophosphamide-resistant nephrotic syndrome at Great Ormond Street Hospital for Children, London. We present our experience of these eight cases and put forward a case for reassessing the effectiveness of vincristine in this disorder. In our series, two children treated with vincristine achieved complete remission with preserved renal function, including relapses in one. Both had primary steroid- and cyclophosphamide-resistant focal segmental glomerulo sclerosis (FSGS). Of the other cases, four also had primary FSGS, one familial FSGS and one mesangioproliferative glomerulonephritis. We discuss in general the pros and cons of vincristine therapy in nephrotic syndrome versus the cytotoxic agents that are currently used and the differences in clinical features among the responders and non-responders in this small group. In addition, we explore why this may have occurred and summarise the literature over the last 25 years, where vincristine appeared to have been beneficial, especially in secondary forms of nephrotic syndrome associated with malignancy. We conclude that vincristine therapy warrants re-examination as it could be a va...Continue Reading

Citations

Jun 25, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joshua Yehuda KausmanHarley Robert Powell
Feb 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rajesh G KrishnanNadeem E Moghal
Dec 3, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zhihui LiYan Yin
Aug 22, 2000·Archives of Disease in Childhood·P A Brogan, M J Dillon
Sep 29, 2011·International Journal of Nephrology·A A NikibakhshA A Macooie
Dec 6, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Asiri S AbeyagunawardenaRichard S Trompeter
May 9, 2002·Expert Opinion on Pharmacotherapy·A AbeyagunawardenaMatthew J Dillon
Feb 7, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J Chemli, A Harbi
Jun 21, 2017·BioMed Research International·Shenal ThalgahagodaAsiri Samantha Abeyagunawardena

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