Vincristine-induced unilateral ptosis in a child

Pediatric Neurology
Orhan GurselRidvan Akin

Abstract

Vincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. Vincristine-induced unilateral palpebral ptosis is a novel finding. Experience with this case suggests conservative treatment, with periodic examination, especially if ptosis is mild.

References

Jan 1, 1986·Journal of Neuro-oncology·D V JacksonH B Muss
Dec 1, 1967·Archives of Ophthalmology·D M AlbertE S Henderson
Jan 13, 2001·Japanese Journal of Clinical Oncology·W S WangP M Chen
Jan 31, 2004·Pediatric Blood & Cancer·Lars MüllerUlrich Göbel
Jul 4, 2006·Indian Journal of Pediatrics·Ali BayAhmet Faik Oner

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Citations

Jul 31, 2013·Journal français d'ophtalmologie·B BattaK Angioi
Jan 1, 2011·BMJ Case Reports·Swaroop Revannasiddaiah, Tapesh Bhattacharyya
Jun 1, 2010·Pakistan Journal of Biological Sciences : PJBS·A A G TantawyA A N A El Aziz
Mar 7, 2013·Cutaneous and Ocular Toxicology·Oktay EsmerEvren Burakgazi-Dalkilic
Jul 12, 2017·Journal of Pediatric Hematology/oncology·Hülya KayilioğluTurkiz Gursel

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