Vincristine-loaded hydroxyapatite nanoparticles as a potential delivery system for bone cancer therapy

Journal of Drug Targeting
Ana Luiza Chaves MaiaDaniel Crístian Ferreira Soares

Abstract

Despite advances in the development of new therapeutic agents and diagnostic imaging techniques, the 5-year survival of osteosarcoma, the most common type of bone cancer, remains practically unaltered for the last three decades at around 60%. Nanoparticle-based carriers have emerged as new class of drug delivery systems that could potentially overcome conventional chemotherapy limitations, by promoting a better drug biodistribution profile by allowing a preferential accumulation of the drug in the desired tissue, while minimising non-targeted tissue toxicity, thus resulting in an improved overall therapeutic effectiveness. Hydroxyapatite nanoparticles (HANP) are known to be biocompatible and non-immunogenic and have shown to be preferentially accumulated in bone tissues being considered a promising carrier to bone tissues. Herein, we successfully synthesised mesoporous hydroxyapatite nanoparticles with mean size of 285.32 ± 10.29 nm and superficial area of 103.5 m2/g, containing significant quantities of chemotherapeutic drug vincristine. A spectrophotometric method was developed and validated aiming to quantify the vincristine (VCR)-loaded in nanoparticles. Chorioallantoic membrane assay revealed relevant anti-angiogenic activ...Continue Reading

References

Aug 30, 2001·Experimental Cell Research·N SogaK A Hruska
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Geerten P van Nieuw AmerongenVictor W M van Hinsbergh
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Beate Kempf-BielackKurt Winkler
Aug 9, 2008·International Journal of Nanomedicine·Wim H De Jong, Paul J A Borm
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Jun 15, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jianian ChenQi Shen
May 3, 2012·Sarcoma·Daniel C AllisonLawrence R Menendez
Aug 28, 2012·International Journal of Nanomedicine·Andrea TautzenbergerAnita Ignatius
Apr 13, 2013·International Journal of Oral and Maxillofacial Surgery·C L FavotM Glogauer
Apr 26, 2014·Oncology Letters·Hongtao HeJun Huang
Jul 12, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Harald RiefUNKNOWN German Bone Research Group
Aug 21, 2014·Angiogenesis·Patrycja Nowak-SliwinskaM Luisa Iruela-Arispe
May 4, 2015·Current Opinion in Pharmacology·Lise Clément-Demange, Philippe Clézardin
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S IsakoffRichard Gorlick
Oct 28, 2015·Current Pharmaceutical Design·Shindu C ThomasSushama Talegaonkar
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yanan SunMingfeng Qiu
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Nov 20, 2016·The Spine Journal : Official Journal of the North American Spine Society·Armin ArshiArya N Shamie
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeina HabliHala Gali-Muhtasib
May 26, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Philip GrossenJörg Huwyler
May 31, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daniel Crístian Ferreira SoaresArmando Silva-Cunha

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Citations

Apr 15, 2021·Biomedical Materials·S Ram PrasadA Jayakrishnan
Jul 9, 2021·Apoptosis : an International Journal on Programmed Cell Death·Xiaofeng DaiJianying Zhang
Jul 28, 2021·Journal of Biomaterials Applications·Hanzheng Chen, Yongchang Yao

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