Abstract
Acute pancreatitis (AP) is a common severe critical illness with a high mortality rate. We aimed to study the effect of vinpocetine (Vinpo) in the treatment of AP because of its anti-inflammatory, antioxidant, and antiapoptotic effects. Thirty two adult male albino Wistar rats were randomized to four groups: control group, Vinpo group (20 mg/kg.P.O.), l-arginine group (two intraperitoneal injections of l-arginine 2.5 g/kg, 1 h apart), and Vinpo + L-arginine group. Vinpo administration was once daily for 7 consecutive days and started 1 h later after l-arginine administration. We measured serum enzyme biomarkers (lipase and amylase), levels of pancreatic malondialdehyde (MDA), total antioxidant capacity (TAC), reduced glutathione (GSH), total sulfhydryl (T-SH), total nitrite/nitrate (NOx), Interluken-6 (IL-6), tumor necrosis factor-alpha (TNF-α), Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Sirtuin type 1 (Sirt1), and caspase-3 activity. Furthermore; histological changes, anti-insulin, and inducible nitric oxide synthase (iNOS) immuno-expressions were examined. l-arginine group displayed AP as manifested by a significant increase in serum lipase and amylase, MDA, NOx, IL-6, TNF-α, caspase-3 with iNOS immuno-expression. Hi...Continue Reading
References
Jun 19, 2002·Analytical Biochemistry·K V H SastryG S Rao
Jul 17, 2007·Orvosi hetilap·Edit BagolyLászló Szapáry
May 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kye-Im JeonChen Yan
Sep 8, 2010·World Journal of Gastroenterology : WJG·Caroline-Mourão MeloMariana-Helena Chaves
Dec 22, 2010·Free Radical Biology & Medicine·Charles AffourtitMartin D Brand
Aug 23, 2011·Pharmacological Reports : PR·Sazal PatyarBikash Medhi
May 25, 2013·World Journal of Gastroenterology : WJG·Ibrahim AkyaziMukaddes Ozcan
Jul 31, 2013·Free Radical Biology & Medicine·Kaipeng HuangHeqing Huang
Jul 31, 2013·The Journal of Physiology·Julia V GerasimenkoOle H Petersen
Mar 7, 2014·Neuroscience Letters·Hongxin WangZhongping Wei
Jul 22, 2014·Experimental Eye Research·Ruozhou Tom LiuJoanne A Matsubara
Mar 17, 2015·Cell Reports·Fiorella GhisaysTom Ellenberger
Mar 31, 2015·PloS One·Kenji W Ruiz-MiyazawaWaldiceu A Verri
Jun 24, 2015·BMC Complementary and Alternative Medicine·Abdulrahman L Al-Malki
Feb 27, 2016·BMC Cancer·Geeske GenrichSusanne Sebens
May 18, 2016·Oxidative Medicine and Cellular Longevity·Seyed Abbas MirmalekEhsan Jangholi
Feb 22, 2017·Endocrine Regulations·N M AzizR A Rifaai
Jun 7, 2017·International Journal of Molecular Medicine·Nian WangKangkai Wang
Jul 15, 2017·Nutrients·Yoo Kyung JeongHyeyoung Kim
Apr 20, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Rania I NadeemBahia M El-Sayeh
Sep 4, 2018·Frontiers in Pharmacology·Man ZhangDa-Qing Chen
Sep 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chenyuan ShiYi Miao
Dec 6, 2018·Journal of Cellular Physiology·Merhan Mamdouh Ragy, Sabreen Mahmoud Ahmed
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohd Asif AnsariSyed Ehtaishamul Haque
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lakshmi Priya PasariChandraiah Godugu