PMID: 9630164Jun 18, 1998Paper

VIP and PACAP enhance IL-6 release and mRNA levels in resting peritoneal macrophages: in vitro and in vivo studies

Journal of Neuroimmunology
C MartinezR P Gomariz

Abstract

Vasoactive intestinal peptide (VIP), a neuropeptide produced by lymphocytes has been previously reported to modulate cytokine expression in T lymphocytes. In this study, we investigated the effects of VIP and of the structurally related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP38) on the production of IL-6 in unstimulated murine peritoneal macrophages. Both neuropeptides stimulate rapidly, specifically, and similarly the production of IL-6, exerting their action through two different receptor/signal transduction systems, i.e., primarily through the binding to VIP1/PACAP receptor followed by adenylate cyclase activation, and partially through the activation of protein kinase C following binding to PACAP-R. VIP and PACAP38 regulate the production of IL-6 at a transcriptional level, affecting the de novo synthesis of this cytokine. The stimulatory in vitro effect correlates with the stimulation of IL-6 expression and release in vivo. These studies suggest that VIP/PACAP play a role in immune system homeostasis, participating in the intricate cytokine network and controlling local immune responses. In addition, the understanding of the factors that regulate the expression and release of IL-6 by macropha...Continue Reading

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Citations

Jun 27, 2013·Cellular and Molecular Neurobiology·Sayako NonakaTeruko Takano-Yamamoto
Nov 1, 2002·Regulatory Peptides·Julia K VoiceEdward J Goetzl
Oct 18, 2002·Peptides·Johan KinhultLars Olaf Cardell
Oct 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Catalina AbadJames A Waschek
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carmen MartinezRosa P Gomariz
Dec 5, 2015·Frontiers in Immunology·Martina Di GiovangiulioGianluca Matteoli
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J KinhultL O Cardell
Jul 23, 2015·Oxidative Medicine and Cellular Longevity·Mounira TliliOlfa Tebourbi
Jan 31, 2013·International Reviews of Immunology·Joan Stein-Streilein
Jun 30, 2006·Journal of Neuroimmunology·Wojciech BikBoguslawa Baranowska
Sep 8, 2009·Journal of Neuroimmunology·María Guadalupe Reyes-García, Fernando García-Tamayo
Apr 16, 2004·Journal of Neurobiology·Kristen L BoeshoreRichard E Zigmond
Jun 10, 2003·Annals of the New York Academy of Sciences·Mario DelgadoRosa P Gomariz
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Jun 1, 2004·Pharmacological Reviews·Mario DelgadoDoina Ganea
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Aug 15, 2018·Journal of Molecular Neuroscience : MN·Catalina Abad, Yossan-Var Tan
Mar 14, 2000·Experimental Eye Research·L N FleisherJ B Ferrell

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