PMID: 7518202Jun 17, 1994Paper

VIP enhances and nitric oxide synthase inhibitor reduces survival of rat lungs perfused ex vivo

Annals of the New York Academy of Sciences
H PakbazS I Said

Abstract

VIP delayed the onset of edematous lung injury in isolated perfused rat lungs by 64%, and was more effective than PGI2 in prolonging lung survival ex vivo. While PGI2 increased survival by 37 min versus Krebs/BSA only, VIP increased it by 2 h and 17 min. On the other hand, inhibition of NO. synthase, which protected the lung against oxidant injury caused by paraquat or X/XO,3 actually hastened the onset of injury caused by prolonged perfusion ex vivo, suggesting opposite roles for NO. in different forms of oxidant injury.

References

Jun 17, 1994·Annals of the New York Academy of Sciences·H BerishaS I Said

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Citations

Jan 1, 1990·Life Sciences·S I Said

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