Viral and cellular enzymes involved in synthesis of mRNA cap structure

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Viral and cellular enzymes involved in synthesis of mRNA cap structure

Abstract

References

Transmethylation and transguanylylation in 5'-RNA capping system isolated from rat liver nuclei

Functions of the 5,-terminal m7G cap in eukaryotic mRNA

Influence of 5'-terminal m7G and 2'--O-methylated residues on messenger ribonucleic acid binding to ribosomes.

Capping of eucaryotic mRNAs

Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator"

Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.

Methylated cap structures in eukaryotic RNAs: structure, synthesis and functions

Mammalian DNA ligases

Isolation and enzymatic characterization of protein lambda 2, the reovirus guanylyltransferase.

Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus.

In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids

trans-spliced Caenorhabditis elegans mRNAs retain trimethylguanosine caps.

Demonstration of enzyme activities required for cap structure formation in infectious bursal disease virus, a member of the birnavirus group

Completion of the genomic sequence of the simian rotavirus SA11: nucleotide sequences of segments 1, 2, and 3

SVLM21, a Sindbis virus mutant resistant to methionine deprivation, encodes an altered methyltransferase

Characterization of cap structures

Association of the Sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1

Nucleotide sequence of the VP4 core protein gene (M4 RNA) of US bluetongue virus serotype 10

The sequence of the reovirus serotype 3 L3 genome segment which encodes the major core protein lambda 1

Proteins covalently linked to viral genomes.

Nucleotides in the encysted embryos of Daphnia magna

5'-terminal cap structure in eucaryotic messenger ribonucleic acids.

Synthesis of Gp4N and Gp3N compounds by guanylyltransferase purified from yeast

Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding, enzyme-guanylate formation, and GMP transfer to RNA.

Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.

Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP

Endogenous enzymatic activities of the avian reovirus S1133: identification of the viral capping enzyme

Expression of Semliki Forest virus nsP1-specific methyltransferase in insect cells and in Escherichia coli

Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases

Mutational analysis of yeast mRNA capping enzyme

The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity

Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus

Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth.

Mutagenesis of the Sindbis virus nsP1 protein: effects on methyltransferase activity and viral infectivity

The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends

Domain structure of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli of a subdomain possessing the RNA 5'-triphosphatase and guanylyltransferase activities and a kinetic comparison to the full-size enzyme.

Characterization of the vaccinia virus RNA 5'-triphosphatase and nucleotide triphosphate phosphohydrolase activities. Demonstrate that both activities are carried out at the same active site.

Mutational analysis of the RNA triphosphatase component of vaccinia virus mRNA capping enzyme

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities

A proposed mechanism of mRNA synthesis and capping by vesicular stomatitis virus

Characterization of an ATPase activity in reovirus cores and its genetic association with core-shell protein lambda1

Characterization of the nucleoside triphosphate phosphohydrolase and helicase activities of the reovirus lambda1 protein.

Citations

A protein tyrosine phosphatase-like protein from baculovirus has RNA 5'-triphosphatase and diphosphatase activities

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

Magnesium-binding studies reveal fundamental differences between closely related RNA triphosphatases.

Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase.

A yeast-based genetic system for functional analysis of viral mRNA capping enzymes

Role of the alfalfa mosaic virus methyltransferase-like domain in negative-strand RNA synthesis

The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei

A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure.

Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor.

Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme.

Identification of alternative splicing and negative splicing activity of a nonsegmented negative-strand RNA virus, Borna disease virus

Flavivirus RNA cap methyltransferase: structure, function, and inhibition.

Control of nonsegmented negative-strand RNA virus replication by siRNA

A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

Mechanisms of action of ribavirin against distinct viruses

Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases

Mutational analysis of a mammalian reovirus mRNA capping enzyme

Efficient preparation and properties of mRNAs containing a fluorescent cap analog: Anthraniloyl-m(7)GpppG

Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector

Cloning, expression, and characterization of avian reovirus guanylyltransferase

Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase

The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core

Kluyveromyces lactis killer plasmid pGKL2: evidence for a viral-like capping enzyme encoded by ORF3

Kluyveromyces lactis cytoplasmic plasmid pGKL2: heterologous expression of Orf3p and proof of guanylyltransferase and mRNA-triphosphatase activities

Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing Mutations

A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus

Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities.

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate

Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain

Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase

Conventional and unconventional mechanisms for capping viral mRNA