Viral and histopathologic correlates of MN and MIB-1 expression in cervical intraepithelial neoplasia

Human Pathology
M ResnickC P Crum

Abstract

A recently studied tumor antigen, MN, has been associated with cervical carcinomas and cervical intraepithelial neoplasms (CIN), suggesting that it may serve as a marker for cervical cancer or cancer risk. To determine if expression of the MN antigen paralleled parameters reflecting viral or biological events in precursor epithelium, MN expression was correlated with MIB-1 expression, morphological phenotype, and human papillomavirus (HPV) distribution and type in a series of CINs. Seventy-three percent, 62% and 83% of CIN I, II, and III, respectively, were MN antigen positive. The proportion of neoplastic cells immunoreactive for MN did not correlate with the CIN grade or with HPV types stratified by their association with cancer. Evaluation of serial sections showed no correlation between the frequency of MN antigen staining, the proportion of MIB-1 immunoreactive cells, or the proportion of HPV positive cells detected by in situ hybridization (ISH). CINs associated with prototypical high risk (HPV 16) types exhibited increased immunostaining for the MIB-1 antigen and were more often classified as HSIL in contrast to the other types. Thus, although MN expression previously has been associated strongly with squamous carcinoma,...Continue Reading

Citations

Aug 8, 2008·Future Oncology·Ashfaq M Khan, Albert Singer
Jan 4, 2001·Gynecologic Oncology·B J QuadeC P Crum
Mar 30, 2004·Gynecologic Oncology·Woong Shick AhnYong-Wan Kim
Oct 17, 2003·Clinics in Laboratory Medicine·Soner Altiok
Sep 19, 2006·Pathology, Research and Practice·Conceição QueirozLuiz Antonio R de Freitas
Feb 28, 2003·Advances in Anatomic Pathology·Marisa R NucciChristopher P Crum
Mar 10, 2001·Advances in Anatomic Pathology·J T KeatingC P Crum
Mar 4, 2003·Nature Reviews. Cancer·Peter BaldwinNicholas Coleman
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Jan 2, 2007·Advances in Anatomic Pathology·Marisa R Nucci, Christopher P Crum
Apr 2, 2010·Virchows Archiv : an International Journal of Pathology·Matthias ChoschzickVolkmar Müller
Jul 13, 2005·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Stephen Soldz, Elizabeth Dorsey
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C P Crum
Jan 18, 2006·Journal of Cancer Research and Clinical Oncology·Joo-Young KimInn-Oc Han
Jan 5, 2002·The American Journal of Surgical Pathology·Edyta C PirogChristina Isacson
Nov 1, 2002·The American Journal of Surgical Pathology·Rüdiger KlaesMagnus von Knebel Doeberitz
Oct 7, 2000·The American Journal of Surgical Pathology·J J ParkC P Crum
Jul 23, 2003·Archives of Pathology & Laboratory Medicine·Mark H Stoler
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·S G Silverberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.