Abstract
A recently studied tumor antigen, MN, has been associated with cervical carcinomas and cervical intraepithelial neoplasms (CIN), suggesting that it may serve as a marker for cervical cancer or cancer risk. To determine if expression of the MN antigen paralleled parameters reflecting viral or biological events in precursor epithelium, MN expression was correlated with MIB-1 expression, morphological phenotype, and human papillomavirus (HPV) distribution and type in a series of CINs. Seventy-three percent, 62% and 83% of CIN I, II, and III, respectively, were MN antigen positive. The proportion of neoplastic cells immunoreactive for MN did not correlate with the CIN grade or with HPV types stratified by their association with cancer. Evaluation of serial sections showed no correlation between the frequency of MN antigen staining, the proportion of MIB-1 immunoreactive cells, or the proportion of HPV positive cells detected by in situ hybridization (ISH). CINs associated with prototypical high risk (HPV 16) types exhibited increased immunostaining for the MIB-1 antigen and were more often classified as HSIL in contrast to the other types. Thus, although MN expression previously has been associated strongly with squamous carcinoma,...Continue Reading
Citations
Sep 13, 2003·Journal of Virology·Kate MiddletonJohn Doorbar
Aug 8, 2008·Future Oncology·Ashfaq M Khan, Albert Singer
Dec 31, 1997·Human Pathology·C M McLachlinC P Crum
Dec 31, 1997·Human Pathology·J Müller-HöckerU Löhrs
Jun 1, 1997·Human Pathology·J R TurnerM B Resnick
Oct 28, 2003·Cancer·Selim M NasserWilliam C Faquin
Mar 1, 1997·Gynecologic Oncology·C J DuntonJ A Carlson
Oct 29, 1998·Gynecologic Oncology·J ParkC P Crum
Jan 4, 2001·Gynecologic Oncology·B J QuadeC P Crum
Oct 26, 1999·Human Pathology·J J ParkC P Crum
Mar 30, 2004·Gynecologic Oncology·Woong Shick AhnYong-Wan Kim
Oct 17, 2003·Clinics in Laboratory Medicine·Soner Altiok
Sep 19, 2006·Pathology, Research and Practice·Conceição QueirozLuiz Antonio R de Freitas
Dec 18, 2001·The Journal of Pathology·A J KruseN Kurten
Feb 28, 2003·Advances in Anatomic Pathology·Marisa R NucciChristopher P Crum
Mar 10, 2001·Advances in Anatomic Pathology·J T KeatingC P Crum
Mar 4, 2003·Nature Reviews. Cancer·Peter BaldwinNicholas Coleman
Aug 5, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rebecca J WolskyKatja Gwin
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Jan 2, 2007·Advances in Anatomic Pathology·Marisa R Nucci, Christopher P Crum
Apr 2, 2010·Virchows Archiv : an International Journal of Pathology·Matthias ChoschzickVolkmar Müller
Jan 10, 1998·The Journal of Pathology·K A HietalaJ K Kellokoski
Jul 13, 2005·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Stephen Soldz, Elizabeth Dorsey
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C P Crum
Jan 18, 2006·Journal of Cancer Research and Clinical Oncology·Joo-Young KimInn-Oc Han
Jan 5, 2002·The American Journal of Surgical Pathology·Edyta C PirogChristina Isacson
Nov 1, 2002·The American Journal of Surgical Pathology·Rüdiger KlaesMagnus von Knebel Doeberitz
Jun 23, 2001·The American Journal of Surgical Pathology·J T KeatingC P Crum
May 6, 2005·Journal of Lower Genital Tract Disease·F AlamedaS Serrano
Oct 7, 2000·The American Journal of Surgical Pathology·J J ParkC P Crum
Jun 8, 2001·Diagnostic Cytopathology·M E BoonL P Kok
Jun 22, 2000·The Journal of General Virology·M StevensonN J Maitland
Jul 23, 2003·Archives of Pathology & Laboratory Medicine·Mark H Stoler
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·S G Silverberg