Viral and host factors associated with the HIV-1 viral load setpoint in adults from Mbeya Region, Tanzania.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Elmar SaathoffMichael Hoelscher

Abstract

The viral load setpoint (VLS) is an important predictor of HIV disease progression, but there is a lack of information regarding the VLS and its possible determinants in African populations. Initially HIV-negative adults from 3 distinct groups(female bar workers, females, and males from the general population)were followed for up to 4 years. The VLS was calculated for 108 seroconverters and associations of the VLS with possible risk factors were analyzed using univariate and multivariate regression. The median VLS for female bar workers, females, and males from the general population were 69,850, 28,600, and 158,000 RNA copies per milliliter, respectively. Significant associations with an elevated viral load were observed for male gender [risk ratio(RR) = 1.83, 95% confidence interval (95% CI) = 1.14 to 2.93], the expression of harmful HLA I alleles (RR = 1.73, 95% CI = 1.13 to 2.66) and multiple infection with different HIV-1 subtypes (RR =1.65, 95% CI = 1.03 to 2.66). Bar workers were considerably more often infected with different HIV-1 subtypes than participants from the general population. Our study confirms that gender and the expression of different HLA class I alleles are important determinants of the viremia at VLS, an...Continue Reading

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Citations

Jun 13, 2013·The Journal of Infectious Diseases·Ujjwal NeogiAnita Shet
May 10, 2012·AIDS·Kathryn E MuessigMyron S Cohen
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Yiming Shao, Carolyn Williamson
Mar 21, 2012·Theoretical Biology & Medical Modelling·Diego F Cuadros, Gisela García-Ramos
Sep 13, 2014·Retrovirology·Adam RitchieNilu Goonetilleke
Nov 16, 2014·The Journal of Infectious Diseases·Gama P BandaweCarolyn Williamson
Nov 15, 2016·AIDS Research and Human Retroviruses·Erik BillingsSodsai Tovanabutra

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