Viral and host proteins involved in picornavirus life cycle.

Journal of Biomedical Science
Jing-Yi LinShin-Ru Shih

Abstract

Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications, including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction between the virus and the host is important for viral replication, virulence and pathogenicity. This article reviews studies of the functions of viral and host factors that are involved in the life cycle of picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and the mechanisms by which the viral and host cell factors are involved in viral replication, viral translation and the switch from translation to RNA replication are then addressed. Understanding how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral infection, will provide insights for the design of novel antiviral agents based on these interactions.

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Citations

May 29, 2012·Current Infectious Disease Reports·Emily Jane Bek, Peter Charles McMinn
Jul 1, 2011·Journal of Virology·Shin-Ru ShihMei-Ling Li
Dec 29, 2011·Frontiers in Bioscience (Scholar Edition)·Heather J Ezelle, Bret A Hassel
Feb 14, 2014·Journal of Biomedical Science·Chee Wah TanYoke Fun Chan
Mar 8, 2014·Journal of Biomedical Science·Jing-Yi Lin, Shin-Ru Shih
Dec 29, 2015·Virology·Beatriz Alvarado HernándezAna Lorena Gutiérrez-Escolano
Feb 2, 2016·Viruses·Jeffrey K F LaiYoke Fun Chan
Jul 6, 2014·Expert Opinion on Biological Therapy·Yu-An KungShin-Ru Shih
Aug 22, 2015·Viruses·Xiang LiWeifeng Shi
Dec 24, 2015·Viruses·Prabuddha S PathinayakePeter A B Wark
Apr 4, 2012·Biochemical and Biophysical Research Communications·Jia-Rong JhengKean Seng Lau
Feb 3, 2011·Virology·Marla I Hertz, Sunnie R Thompson
Feb 14, 2015·Virus Research·Bader AlhatlaniIan Goodfellow
Dec 25, 2012·Antiviral Research·Luqing ShangZheng Yin
Dec 3, 2014·Biochimie·Claudia PatiñoSilvio Urcuqui-Inchima
Jun 3, 2016·Current Opinion in Microbiology·Ana Shulla, Glenn Randall
Jun 23, 2016·Virus Research·Sajna Anand SadanandanDan Hultmark
Dec 22, 2016·Viruses·Wendy Ullmer, Bert L Semler
Dec 6, 2016·Acta Crystallographica. Section F, Structural Biology Communications·Stavroula FiliIrene Margiolaki

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Methods Mentioned

BETA
nucleotide exchange
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immunodepletion
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Software Mentioned

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