Viral behavior of paracrystalline inclusions in osteoclasts of Paget's disease of bone

Ultrastructural Pathology
S AbeA Tateishi

Abstract

Fresh tissues from six patients with Paget's disease of bone were examined ultrastructurally to investigate whether the characteristic paracrystalline inclusions in pagetic osteoclasts revealed viral behavior. These inclusions appeared as microfilamentous aggregates in both nuclei and cytoplasm of the osteoclasts in all six cases. The filamentous elements of the inclusions with a diameter of 11-15 nm showed tubular structures with a central electron-lucent zone measuring 5-7 nm in diameter. Viral budding-like structures containing these inclusions were found at the peripheral cytoplasm or cell processes in the ruffled border of some pagetic osteoclasts in two cases. The inclusions in the budding-like structures were often arrayed in a parallel fashion on the cytoplasmic side of the cell membranes of extruded cytoplasm or cell processes. Virion-like particles were also found in the extracellular spaces of the ruffled border. Marked nuclear degeneration was often seen in pagetic osteoclasts of three cases, although other nuclei in the same osteoclasts appeared normal. The degenerated nuclei showed nuclear ring formation where destroyed nuclear membranes were seen and disappearance of nuclear matrices was noted. Since the modifica...Continue Reading

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Citations

Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F R Singer
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H HelfrichS H Ralston
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Jan 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frederick R SingerG David Roodman
Aug 29, 2006·Journal of Bone and Mineral Metabolism·Shinjiro TakataHideki Yoshikawa
Dec 18, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sune Land Bloch, Mads Sølvsten Sørensen
Mar 27, 2004·Clinical Orthopaedics and Related Research·Theodore J ChomaH Thomas Temple
Apr 6, 2004·The Laryngoscope·Edwin M Monsell

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