Viral Coagulopathy in Patients With COVID-19: Treatment and Care

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Nickolas KipshidzeJawed Fareed

Abstract

COVID-19 has proven to be particularly challenging given the complex pathogenesis of SARS-CoV-2. Early data have demonstrated how the host response to this novel coronavirus leads to the proliferation of pro-inflammatory cytokines, massive endothelial damage, and generalized vascular manifestations. While SARS-CoV-2 primarily targets the upper and lower respiratory tract, other organ systems are also affected. SARS-CoV-2 relies on 2 host cell receptors for successful attachment: angiotensin-converting enzyme 2 and transmembrane protease serine 2. Clinicopathologic reports have demonstrated associations between severe COVID-19 and viral coagulopathy, resulting in pulmonary embolism; venous, arterial, and microvascular thrombosis; lung endothelial injury; and associated thrombotic complications leading to acute respiratory distress syndrome. Viral coagulopathy is not novel given similar observations with SARS classic, including the consumption of platelets, generation of thrombin, and increased fibrin degradation product exhibiting overt disseminated intravascular coagulation-like syndrome. The specific mechanism(s) behind the thrombotic complications in COVID-19 patients has yet to be fully understood. Parenteral anticoagulants,...Continue Reading

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Citations

Sep 15, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Antonis S ManolisHelen Melita
Mar 17, 2021·SN Comprehensive Clinical Medicine·Umair Nasir, Sarfraz Ahmad
Apr 4, 2021·Journal of Clinical Medicine·Mohammad Suhail AkhterArijit Biswas
Apr 25, 2021·Thrombosis Research·Nishant R TiwariSanjay K Agarwal
Jun 4, 2021·Journal of Thrombosis and Thrombolysis·Oktay Gülcüİbrahim Halil Tanboğa
Jun 1, 2021·Frontiers in Bioengineering and Biotechnology·Elda M Melchor-MartínezJuan Eduardo Sosa-Hernández
Jul 3, 2021·Journal of Clinical Medicine·Akitaka YamamotoKatsue Suzuki-Inoue

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