Viral dominance of reassortants between canine influenza H3N2 and pandemic (2009) H1N1 viruses from a naturally co-infected dog

Virology Journal
Woonsung NaD Song

Abstract

Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) influenza virus (pH1N1) has been observed in a broad range of animal species. Viral dominance and characterization of the reassortants of both viruses was undertaken in the present study. Here we describe the viral dominance of 23 CIV reassortants between pH1N1 and canine H3N2 influenza viruses from a naturally co-infected dog. These results indicate that the M gene of pandemic H1N1 and the HA gene of canine H3N2 are predominant in the reassortants. Furthermore, unlike the original canine H3N2 virus, some reassortants showed high pathogenicity in mice. This study suggests that continuous monitoring of influenza infection in companion animals may be necessary to investigate the potential of the emergence of novel influenza viruses.

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Aug 25, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shoujun LiXiu-Feng Wan
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Oct 9, 2013·Virus Genes·Napawan BunpapongAlongkorn Amonsin

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Citations

Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Aug 5, 2016·Clinical and Experimental Vaccine Research·Woonsung NaDaesub Song
Jan 25, 2020·Transboundary and Emerging Diseases·Woonsung NaDaesub Song
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Brian R WasikColin R Parrish
Jan 5, 2021·The Journal of Infectious Diseases·Christine H T BuiMichael C W Chan

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