Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Sharon R LewinGregory J Dore

Abstract

Following treatment of hepatitis B virus (HBV) infection with nucleos(t)ide reverse transcriptase inhibitors (NRTIs), there is a biphasic clearance of HBV, similar to that seen following treatment of human immunodeficiency virus-1 (HIV-1) and hepatitis C virus. Little is known about the impact of combination NRTIs and HIV-1 coinfection on HBV viral kinetic parameters following the initiation of HBV-active highly active antiretroviral therapy (HAART). HIV-1-HBV coinfected patients (n = 21) were enrolled in a viral kinetics substudy of the Tenofovir in HIV-1-HBV Coinfection study (TICO). TICO was a randomized (1:1:1) trial of tenofovir disoproxil fumarate (TDF, 300 mg) versus lamivudine (LMV, 300 mg) versus TDF/LMV within an efavirenz based HAART regimen initiated in HIV-1-HBV coinfected antiretroviral naïve individuals in Thailand. HBV DNA was measured frequently over the first 56 days. To fit the viral load data, we used a model of HBV kinetics that allows the estimation of treatment effectiveness, viral clearance and infected cell loss. We observed a biphasic decline in HBV DNA in almost all patients. We did not observe any significant differences in HBV viral dynamic parameters between the three treatments groups. Overall, me...Continue Reading

References

Dec 21, 1995·The New England Journal of Medicine·J L DienstagM Rubin
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A NowakH McDade
Nov 1, 1996·Annals of Internal Medicine·Y BenhamouP Opolon
Jul 9, 1998·The New England Journal of Medicine·C L LaiD F Gray
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F ColinP Marcellin
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M TsiangC S Gibbs
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K LauS Lam
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A de ManD DeHertogh
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S R LewinA S Perelson
Jun 22, 2002·Journal of Hepatology·Leonieke M M WoltersRobert A de Man
Dec 21, 2002·Lancet·Chloe L ThioUNKNOWN Multicenter AIDS Cohort Study
Nov 19, 2003·The Journal of Infectious Diseases·Francesca J TorrianiAlan S Perelson
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vassiliki-Anastasia SypsaAngelos Hatzakis
Jan 19, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·T E M S de Vries-SluijsM E van der Ende
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yves BenhamouUNKNOWN TECOVIR Study Group
Jun 9, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrew H TalalAlan S Perelson
Aug 16, 2006·Archives of Internal Medicine·Rainer WeberJens D Lundgren
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kumar VisvanathanStephen Locarnini
Jan 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael W FriedMatei Popescu
Aug 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gail V MatthewsGregory J Dore
Oct 4, 2008·The New England Journal of Medicine·Jules L Dienstag

❮ Previous
Next ❯

Citations

Oct 28, 2009·Current Infectious Disease Reports·Colleen F Kelley, Wendy S Armstrong
Feb 18, 2010·HIV Therapy·David M Iser, Sharon R Lewin
Sep 2, 2011·Digestive Diseases and Sciences·Marco MontagnaniGiuseppe Mazzella
Dec 29, 2015·European Journal of Gastroenterology & Hepatology·Pierre O SellierJean-François Bergmann
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Olivier LadaPatrick Marcellin
Nov 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ashish Goyal, John M Murray
Aug 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeremie GuedjHarel Dahari
Feb 1, 2019·World Journal of Gastroenterology : WJG·Murali GanesanNatalia A Osna
Oct 20, 2020·Journal of Viral Hepatitis·Antonio GonçalvesJérémie Guedj

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.