Nov 3, 2009

Viral entry mechanisms: the increasing diversity of paramyxovirus entry

The FEBS Journal
Everett Clinton SmithRebecca Ellis Dutch

Abstract

The paramyxovirus family contains established human pathogens such as the measles virus and human respiratory syncytial virus, as well as emerging pathogens including the Hendra and Nipah viruses and the recently identified human metapneumovirus. Two major envelope glycoproteins, the attachment protein and the fusion protein, promote the processes of viral attachment and virus-cell membrane fusion required for entry. Although common mechanisms of fusion protein proteolytic activation and the mechanism of membrane fusion promotion have been shown in recent years, considerable diversity exists in the family relating to receptor binding and the potential mechanisms of fusion triggering.

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References

Mentioned in this Paper

Nipah Virus
Measles virus
Pathogenicity
Glycoproteins
Human respiratory syncytial virus
Paramyxovirinae
Mumps Virus Fusion Protein
Proteolytic Enzyme
Measles virus preparation
Paramyxovirus, NOS

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