Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons

Science Signaling
Daniela BruniNolwenn Jouvenet

Abstract

Although plasmacytoid dendritic cells (pDCs) represent a rare immune cell type, they are the most important source of type I interferons (IFNs) upon viral infection. Phagocytosed RNA viruses and RNA virus-infected cells are detected by pDCs with the endosomal pattern recognition receptor (PRR) toll-like receptor 7 (TLR7). We showed that replication of the yellow fever live vaccine YF-17D in human pDCs and pDC-like cell lines stimulated type I IFN production through RIG-I (retinoic acid-inducible gene I), a member of the RIG-I-like receptor (RLR) family of cytosolic PRRs. Thus, human pDCs sense replicative viral RNA. In contrast, direct contact between pDCs and YF-17D-infected cells stimulated a TLR7-dependent, viral replication-independent production of type I IFN. We also showed that the RLR pathway was dampened by the activities of interleukin-1 receptor-associated kinases 1 and 4 (IRAK1 and IRAK4), which are downstream effectors of the TLR7 pathway, suggesting that both kinases play opposing roles downstream of specific PRRs. Together, these data suggest that a virus can stimulate either TLR or RLR signaling in the same cell, depending on how its nucleic acid content is delivered.

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M O DiazJ D Rowley
Nov 20, 2001·Nature Immunology·C Asselin-PaturelG Trinchieri
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 22, 1965·The New England Journal of Medicine·E F WHEELOCK, W A SIBLEY
Dec 24, 2003·Advances in Virus Research·Thomas P Monath, Alan D Barrett
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
Jan 5, 2005·Virology·Christopher T JonesRichard J Kuhn
Jul 26, 2005·Immunity·Hiroki KatoShizuo Akira
Oct 15, 2005·The Journal of Clinical Investigation·Anne-Sophie BeignonNina Bhardwaj
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurence ChaperotJoël Plumas
Apr 25, 2006·Virology·Laura StrahleDaniel Kolakofsky
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kosuke MatsuiShizuo Akira
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer P WangDaniel H Libraty
Feb 3, 2007·Science·Heung Kyu LeeAkiko Iwasaki
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Nov 6, 2007·Immunological Reviews·Shen-Ying ZhangJean-Laurent Casanova
Jul 11, 2008·Immunological Reviews·Franck J Barrat, Robert L Coffman
Jul 22, 2008·Nature Reviews. Immunology·Michel GillietYong-Jun Liu
Nov 26, 2008·Nature Immunology·Troy D QuerecBali Pulendran
Dec 3, 2008·The Journal of Experimental Medicine·Denis GaucherRafick-Pierre Sékaly
Apr 22, 2009·Cell Host & Microbe·Maria-Dolores Fernandez-GarciaAli Amara
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Serena ChangGyongyi Szabo
Feb 11, 2010·Cell·Jan RehwinkelCaetano Reis e Sousa
Mar 3, 2010·Annual Review of Immunology·Virginia PascualJacques Banchereau
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ken TakahashiFrancis V Chisari
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene Y ChiangJane L Grogan
Jan 12, 2011·Annual Review of Immunology·Boris ReizisVanja Sisirak
Mar 8, 2011·PLoS Pathogens·Alice LepelleyOlivier Schwartz
Apr 13, 2011·European Journal of Cell Biology·Katharina Eisenächer, Anne Krug
Apr 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith N MandlMark B Feinberg
Aug 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajiv Lochan TiwariManoj Kumar Barthwal
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kristopher ClarkPhilip Cohen
Feb 1, 2010·Viruses·Jorge L Muñoz-Jordán, Brenda L Fredericksen
Nov 18, 2011·Journal of Virology·Réjane RuaOlivier Schwartz
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shuye ZhangGyongyi Szabo

❮ Previous
Next ❯

Citations

Aug 22, 2015·Viruses·Sonia AssilMarlène Dreux
Jul 23, 2015·Viruses·Danielle BlondelMounira K Chelbi-Alix
Jan 10, 2018·Immunology·Matthew Collin, Venetia Bigley
Aug 18, 2017·Journal of Virology·Lise ChauveauOlivier Schwartz
Oct 18, 2018·Annual Review of Pathology·Mary K CrowKyriakos A Kirou
Aug 15, 2019·PLoS Neglected Tropical Diseases·Lucie DanetNolwenn Jouvenet
Jul 8, 2015·Journal of Leukocyte Biology·Bastiaan A BlokMihai G Netea
Oct 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Axel Ronald SchulzAndreas Thiel
Apr 12, 2017·Viruses·Alan M Watson, William B Klimstra
Feb 15, 2018·Seminars in Cell & Developmental Biology·Solana AlculumbreVassili Soumelis
Oct 9, 2021·Clinical Science·Laura MarongiuFrancesca Granucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.