Viral eradication reduces all-cause mortality in patients with chronic hepatitis C virus infection: a propensity score analysis

Liver International : Official Journal of the International Association for the Study of the Liver
Toshifumi TadaJunko Tanaka

Abstract

Eradication of hepatitis C virus (HCV) by interferon (IFN)-based therapy has been reported to reduce all-cause mortality rates in patients with chronic HCV infection. However, the impact of HCV eradication on non-liver-related mortality including the causes of death has not been sufficiently investigated in patients with chronic HCV infection. We enrolled 2743 patients with chronic HCV infection. Causes of death, incidence of hepatocellular carcinoma (HCC), and all-cause mortality including non-liver-related diseases, were analysed. Of these 2743 patients, 587 achieved sustained virological response (SVR) (eradication of HCV) by IFN-based therapy (IFN-SVR), 475 did not (without HCV eradication) (IFN-non-SVR), or 1681 did not receive IFN-based therapy (non-IFN patients) (Cohort 1); of these, 309 were selected from IFN-SVR and non-IFN groups using propensity score matching (Cohort 2).The median follow-up duration was 11.4 years. In Cohort 1 patients, mortality rates from non-liver-related diseases were 71.0% (22/31) in IFN-SVR patients, 34.9% (37/106) in IFN-non-SVR patients and 50.0% (248/496) in non-IFN patients respectively. In Cohort 2 patients, mortality rates from non-liver-related diseases were 72.2% (13/18) in IFN-SVR pat...Continue Reading

References

Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YanoK Okuda
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Aug 14, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I BalikH Yasa
Jul 30, 2002·Gastroenterology·Haruhiko YoshidaMasao Omata
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Dec 1, 2005·Cleveland Clinic Journal of Medicine·Aman Ali, Nizar N Zein
Jan 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuji AraseHiromitsu Kumada
Jul 20, 2012·The Journal of Infectious Diseases·Mei-Hsuan LeeUNKNOWN R.E.V.E.A.L.-HCV Study Group
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Chun HsuChun-Ying Wu
Dec 18, 2013·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Dec 3, 2014·Journal of Hepatology·Rachel H Westbrook, Geoffrey Dusheiko
Apr 1, 2012·Hepatology International·Masao OmataGeoffrey W McCaughan

❮ Previous
Next ❯

Citations

Apr 7, 2016·Journal of Hepatology·Shruti H Mehta, David L Thomas
Mar 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Raoel Maan, Adriaan J van der Meer
Sep 20, 2016·Journal of Hepatology·Adriaan J van der Meer, Marina Berenguer
Oct 27, 2016·Infectious Diseases and Therapy·Roberto Nuño SolinísYuri Sanchez Gonzalez
Oct 13, 2018·Expert Review of Clinical Pharmacology·Fabrizio Fabrizi, Piergiorgio Messa
Oct 31, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ryo Fukuda, Yasuteru Kondo
Mar 23, 2017·World Journal of Hepatology·Francesca Romana PonzianiAntonio Gasbarrini
May 26, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Vincenza Calvaruso, Antonio Craxì
Dec 5, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ching-Chih HuRong-Nan Chien
May 14, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshifumi TadaJunko Tanaka
May 26, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Alfredo Alberti, Sara Piovesan
Jun 1, 2018·Journal of Occupational Medicine and Toxicology·Claudia WestermannAlbert Nienhaus
Mar 16, 2017·BMC Medicine·Thomas F BaumertYujin Hoshida
Dec 3, 2016·Journal of Occupational Medicine and Toxicology·Claudia WestermannAlbert Nienhaus
Dec 4, 2020·World Journal of Gastroenterology : WJG·Cristina Maria MuzicaAnca Trifan
Aug 26, 2021·Journal of Occupational Medicine and Toxicology·Claudia WestermannAlbert Nienhaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.